Holland J F, Ohnuma T
Cancer Treat Rep. 1979 Jun;63(6):1013-8.
The sensitivity of the neoplastic cell to amino acid deprivation shows considerable variation. The responsiveness of human leukemic cell cultures to L-asparaginase indicates that those of T cell origin are much more sensitive to the action of this L-asparagine-depleting enzyme than those of B cell origin. A cautionary note is raised concerning amino acid analogs. Minor changes such as substituting selenium for sulfur to make seleno-L-methionine rather than L-methionine may lead to considerable differences in their respective metabolic polls in vivo. A systemic survey of amino acid requirements of human neoplasms is desirable before designing new analogs.
肿瘤细胞对氨基酸剥夺的敏感性表现出很大差异。人类白血病细胞培养物对L-天冬酰胺酶的反应表明，T细胞起源的细胞比B细胞起源的细胞对这种消耗L-天冬酰胺的酶的作用更为敏感。关于氨基酸类似物需谨慎对待。一些微小变化，如用硒取代硫制成硒代-L-蛋氨酸而非L-蛋氨酸，可能会导致它们在体内各自代谢途径出现显著差异。在设计新的类似物之前，对人类肿瘤的氨基酸需求进行全面调查是很有必要的。
