A novel regulatory region controls IgH locus transcription and switch recombination to a subset of isotypes.
作者信息
Amoretti-Villa Rocío, Rogier Mélanie, Robert Isabelle, Heyer Vincent, Reina-San-Martin Bernardo
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Illkirch, France.
出版信息
Cell Mol Immunol. 2019 Nov;16(11):887-889. doi: 10.1038/s41423-019-0267-4. Epub 2019 Aug 5.
Abstract
摘要
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A novel regulatory region controls IgH locus transcription and switch recombination to a subset of isotypes.一个新的调控区域控制免疫球蛋白重链（IgH）基因座的转录以及向一部分同种型的类别转换重组。
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本文引用的文献
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The IgH 3' regulatory region super-enhancer does not control IgA class switch recombination in the B1 lineage.免疫球蛋白重链（IgH）3'调控区超级增强子并不控制B1细胞系中的IgA类别转换重组。
Cell Mol Immunol. 2018 Mar;15(3):289-291. doi: 10.1038/cmi.2017.103. Epub 2017 Oct 9.
2
A transcriptional serenAID: the role of noncoding RNAs in class switch recombination.转录镇静剂：非编码 RNA 在类别转换重组中的作用。
Int Immunol. 2017 Apr 1;29(4):183-196. doi: 10.1093/intimm/dxx027.
3
Inducible CTCF insulator delays the 3' regulatory region-mediated activation of germline promoters and alters class switching.诱导型 CTCF 绝缘子延迟 3' 调控区介导的生殖系启动子的激活，并改变类别转换。
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6092-6097. doi: 10.1073/pnas.1701631114. Epub 2017 May 22.
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Enhancers as non-coding RNA transcription units: recent insights and future perspectives.增强子作为非编码 RNA 转录单元：最新见解与未来展望。
Nat Rev Genet. 2016 Apr;17(4):207-23. doi: 10.1038/nrg.2016.4. Epub 2016 Mar 7.
5
Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination.在类别转换重排过程中，中介体促进免疫球蛋白重链基因座处的转录激活和动态远距离相互作用。
J Exp Med. 2016 Mar 7;213(3):303-12. doi: 10.1084/jem.20141967. Epub 2016 Feb 22.
6
Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.靶向染色质谱分析揭示了 IgH 和 IgL 链基因座中的新型增强子。
J Immunol. 2014 Feb 1;192(3):1064-70. doi: 10.4049/jimmunol.1302800. Epub 2013 Dec 18.
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Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.IGH 基因座 VH 基因区的灵活长距离环有助于产生多样化的抗体库。
Immunity. 2013 Aug 22;39(2):229-44. doi: 10.1016/j.immuni.2013.08.011.
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S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.在类别转换重组过程中，远距离定位的转录元件和活化诱导的胞嘧啶脱氨酶促进了S-S突触形成。
Immunity. 2007 Nov;27(5):711-22. doi: 10.1016/j.immuni.2007.09.007. Epub 2007 Nov 1.
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