甲状腺乳头状癌筛状-桑葚状变体及其与家族性腺瘤性息肉病的关联。
Cribriform-morular variant of papillary thyroid carcinoma and its association with familial adenomatous polyposis.
作者信息
Perez Alejandro, Findeis Sarah, Agarwal Atin, Berry Julia, King Katie
机构信息
Texas A&M University College of MedicineBryanTexas.
Department of Pathology, Baylor University Medical CenterDallasTexas.
出版信息
Proc (Bayl Univ Med Cent). 2019 Jun 10;32(3):399-401. doi: 10.1080/08998280.2019.1616865. eCollection 2019 Jul.
Abstract
The cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is an uncommon variant of papillary thyroid carcinoma. CMV-PTC can be associated with familial adenomatous polyposis (FAP), an autosomal-dominant polyposis syndrome caused by a mutation in the gene that leads to a disruption of the Wnt/beta-catenin pathway. Understanding the relation between CMV-PTC and FAP is a diagnostic tool for both pathologists and clinicians, because FAP has several implications for patients and their families.
摘要
甲状腺乳头状癌筛状-桑葚状变异型（CMV-PTC）是甲状腺乳头状癌的一种罕见变异型。CMV-PTC可能与家族性腺瘤性息肉病（FAP）相关，FAP是一种常染色体显性息肉病综合征，由一个基因的突变引起，该突变导致Wnt/β-连环蛋白信号通路的破坏。了解CMV-PTC与FAP之间的关系对病理学家和临床医生而言都是一种诊断工具，因为FAP对患者及其家族有诸多影响。
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