长期使用阿片类镇痛药引起的继发性肾上腺皮质功能减退。
Secondary adrenal insufficiency induced by long-term use of opioid analgesics.
作者信息
Ali Emad S, Peiris Alan N
机构信息
Department of Family and Community Medicine, Texas Tech University Health Science CenterLubbockTexas.
Department of Internal Medicine and Clinical Research Institute, Texas Tech University Health Science CenterLubbockTexas.
出版信息
Proc (Bayl Univ Med Cent). 2019 May 21;32(3):417-418. doi: 10.1080/08998280.2019.1600180. eCollection 2019 Jul.
The effects of long-term use of opioid analgesics on the hypothalamic-pituitary-adrenal axis are not well recognized. We report a 41-year-old woman on chronic opioid therapy hospitalized for cardiovascular collapse following a right stellate ganglion nerve block. She developed severe hypotension after the procedure. Morning cortisol was low. The results from the cosyntropin test were consistent with secondary adrenal insufficiency. Her secondary adrenal insufficiency was likely due to long-term use of opioid analgesics for pain in the absence of other etiologies.
长期使用阿片类镇痛药对下丘脑-垂体-肾上腺轴的影响尚未得到充分认识。我们报告一名41岁长期接受阿片类药物治疗的女性，在接受右侧星状神经节神经阻滞后因心血管衰竭住院。术后她出现严重低血压。晨皮质醇水平较低。促肾上腺皮质激素试验结果符合继发性肾上腺功能不全。在没有其他病因的情况下，她的继发性肾上腺功能不全可能是由于长期使用阿片类镇痛药止痛所致。
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