Delitala G, Devilla L, Arata L
Acta Endocrinol (Copenh). 1981 Jun;97(2):150-6. doi: 10.1530/acta.0.0970150.
The role of endogenous opioid receptors on anterior pituitary hormone secretion was evaluated by the administration of the opioid receptor antagonist naloxone. The infusion of naloxone (8 mg iv followed by 4mg/h for 3 h) did not alter basal growth hormone (GH), prolactin (Prl) and thyrotrophin (TSH) secretion but produced a significant rise in cortisol and gonadotrophins in normal man. The infusion of the opiate antagonist appeared to increase the rate and amplitude of luteinizing hormone (LH) pulsatility. Naloxone pre-medication (10 mg iv 30 min before testing) did not alter the pituitary response to TRH and LRH stimulation. These results demonstrate that naloxone can modify basal anterior pituitary hormone secretion and strongly suggest an endogenous opioid modulation of some of these hormones.
通过给予阿片受体拮抗剂纳洛酮，评估内源性阿片受体对垂体前叶激素分泌的作用。静脉注射纳洛酮（8毫克，随后以每小时4毫克的速度持续3小时）并未改变基础生长激素（GH）、催乳素（Prl）和促甲状腺激素（TSH）的分泌，但在正常男性中导致皮质醇和促性腺激素显著升高。注射阿片拮抗剂似乎增加了促黄体生成素（LH）脉冲式分泌的频率和幅度。预先注射纳洛酮（测试前30分钟静脉注射10毫克）并未改变垂体对促甲状腺激素释放激素（TRH）和促性腺激素释放激素（LRH）刺激的反应。这些结果表明，纳洛酮可改变垂体前叶激素的基础分泌，并强烈提示内源性阿片对其中一些激素具有调节作用。
