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本文引用的文献

1
Full-Thickness Cartilage Defects Are Important Independent Predictive Factors for Progression to Total Knee Arthroplasty in Older Adults with Minimal to Moderate Osteoarthritis: Data from the Osteoarthritis Initiative.全层软骨缺损是老年中轻度骨关节炎患者进展为全膝关节置换术的重要独立预测因素：来自骨关节炎倡议的数据。
J Bone Joint Surg Am. 2019 Jan 2;101(1):56-63. doi: 10.2106/JBJS.17.01657.
2
Osteochondral Allograft Transplantation for Treatment of Medial Femoral Condyle Defect.异体骨软骨移植治疗股骨内侧髁缺损
Arthrosc Tech. 2017 Aug 7;6(4):e1239-e1244. doi: 10.1016/j.eats.2017.04.010. eCollection 2017 Aug.
3
The role of growth factors in cartilage repair.生长因子在软骨修复中的作用。
Clin Orthop Relat Res. 2011 Oct;469(10):2706-15. doi: 10.1007/s11999-011-1857-3.
4
Surgical management of articular cartilage defects of the knee.膝关节关节软骨缺损的外科治疗
J Bone Joint Surg Am. 2010 Oct 20;92(14):2470-90.
5
Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study.基质诱导自体软骨细胞移植与微骨折术治疗膝关节软骨缺损的 2 年随机研究。
Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):519-27. doi: 10.1007/s00167-009-1028-1.
6
Focal cartilage defects in the knee impair quality of life as much as severe osteoarthritis: a comparison of knee injury and osteoarthritis outcome score in 4 patient categories scheduled for knee surgery.膝关节局灶性软骨缺损对生活质量的影响与严重骨关节炎相当：4 种拟行膝关节手术患者类别的膝关节损伤和骨关节炎结局评分比较。
Am J Sports Med. 2010 Feb;38(2):231-7. doi: 10.1177/0363546509352157. Epub 2009 Dec 30.
7
Autologous chondrocyte implantation improves patellofemoral cartilage treatment outcomes.自体软骨细胞移植可改善髌股关节软骨的治疗效果。
Clin Orthop Relat Res. 2007 Oct;463:187-94.
8
Results after microfracture of full-thickness chondral defects in different compartments in the knee.膝关节不同部位全层软骨缺损微骨折后的结果。
Osteoarthritis Cartilage. 2006 Nov;14(11):1119-25. doi: 10.1016/j.joca.2006.05.003. Epub 2006 Jul 11.
9
Minced cartilage without cell culture serves as an effective intraoperative cell source for cartilage repair.未经细胞培养的切碎软骨可作为软骨修复术中有效的细胞来源。
J Orthop Res. 2006 Jun;24(6):1261-70. doi: 10.1002/jor.20135.
10
A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes.一项关于马赛克自体骨软骨移植与微骨折术治疗年轻运动员膝关节骨软骨损伤的前瞻性随机临床研究。
Arthroscopy. 2005 Sep;21(9):1066-75. doi: 10.1016/j.arthro.2005.06.018.

软骨移植

Cartilage Grafting.

作者信息

Agrawal Nikhil, Yari Shawn, Engles Drew, Reece Edward M

机构信息

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Akron Children's Hospital Specialty Care, Akron, Ohio.

出版信息

Semin Plast Surg. 2019 Aug;33(3):200-203. doi: 10.1055/s-0039-1693432. Epub 2019 Aug 2.

DOI:10.1055/s-0039-1693432
PMID:31384236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6680078/
Abstract

Arthritis remains a widespread and yet unsolved therapeutic dilemma. Cartilage grafting has proven to be difficult and satisfactory results are often elusive. There are several inherent difficulties. These include both chondrocyte migration and the lack of sufficient uptake of nutrients to allow for graft survival. With autografts, there is also the paucity of symptom-free donor sites. Accordingly, multiple alternative therapies for cartilage regeneration and/or substitution have been developed over time. In this article, the authors shall discuss the options for the treatment of damaged cartilage with a focus on the cartilage grafting techniques.

摘要

关节炎仍然是一个普遍存在且尚未解决的治疗难题。软骨移植已被证明是困难的，往往难以获得令人满意的结果。存在几个固有的困难。这些困难包括软骨细胞迁移以及缺乏足够的营养物质摄取以维持移植物的存活。对于自体移植，还存在无症状供体部位不足的问题。因此，随着时间的推移，已经开发出多种用于软骨再生和/或替代的替代疗法。在本文中，作者将重点讨论软骨移植技术，探讨治疗受损软骨的选择。