Aslanabadi Naser, Separham Ahmad, Valae Hiagh Leyla, Karkon Shayan Farid, Toufan Mehrnoush, Ghaffari Samad, Enamzadeh Elgar
Cardiovascular Research Center, Tabriz University of medical sciences, Tabriz, Iran.
Students' Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
J Cardiovasc Thorac Res. 2019;11(2):95-99. doi: 10.15171/jcvtr.2019.17. Epub 2019 May 23.
Rheumatic heart disease (RHD) is a relatively common cause of mortality among patients in the developing countries, and pure mitral valve failure is the most common form of RHD. An increase in the mean platelet volume (MPV) is considered as an independent risk factor for many cardiovascular diseases. This study aimed to evaluate the association of MPV with echocardiographic findings in patients with severe rheumatic mitral stenosis. In a descriptive, analytical study, 100 patients with severe rheumatic mitral stenosis referred to Shahid Madani hospital of Tabriz University of Medical Sciences and 100 age & sex-matched healthy individuals were included the study. MPV and echocardiographic findings including Wilkins score, left ventricular ejection fraction (LVEF), pulmonary artery systolic pressure, and left atrial spontaneous echo contrast (LASEC) were evaluated in both groups. MPV in the case group was 10.45±0.98 and in the control group was 9.88±0.83. MPV in the patient's groups was significantly higher than the control group ( = 0.001). Also, MPV in patients with positive LASEC findings was 10.69 ± 1.01 and in patients with negative LASEC findings was 10.25 ± 0.91. The difference was found to be statistically significant ( = 0.028). Patients with rheumatic mitral stenosis has a higher MPV compared to the healthy individuals, and it is associated with LASEC sign seen in echocardiography.
风湿性心脏病（RHD）是发展中国家患者中相对常见的死亡原因，而单纯二尖瓣衰竭是RHD最常见的形式。平均血小板体积（MPV）增加被认为是许多心血管疾病的独立危险因素。本研究旨在评估重度风湿性二尖瓣狭窄患者中MPV与超声心动图检查结果之间的关联。在一项描述性分析研究中，纳入了100例转诊至大不里士医科大学沙希德·马达尼医院的重度风湿性二尖瓣狭窄患者以及100名年龄和性别匹配的健康个体。对两组患者的MPV以及超声心动图检查结果进行评估，包括威尔金斯评分、左心室射血分数（LVEF）、肺动脉收缩压和左心房自发显影（LASEC）。病例组的MPV为10.45±0.98，对照组为9.88±0.83。病例组的MPV显著高于对照组（P = 0.001）。此外，LASEC检查结果为阳性的患者MPV为10.69±1.01，检查结果为阴性的患者MPV为10.25±0.91。差异具有统计学意义（P = 0.028）。与健康个体相比，风湿性二尖瓣狭窄患者的MPV更高，且与超声心动图中所见的LASEC征象相关。
