Martin R F, Janghorbani M, Young V R
Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge.
JPEN J Parenter Enteral Nutr. 1988 Jul-Aug;12(4):351-5. doi: 10.1177/0148607188012004351.
The purpose of this study was to explore the fate of a single dose of labeled selenium as determined by its route of administration. Thus, the appearance of a stable isotope of selenium, administered as 74-Se-selenite, was measured in plasma, urine, and feces, with neutron activation analysis, following a 81.7 micrograms dose of 74Se-selenite given either intravenously or orally in two groups (n = 4) of healthy, young adult men, who were otherwise maintained on a diet providing a constant and adequate selenium intake. From these isotopic data, measurable parameters of urine excretion, total body retention and selenite-exchangeable metabolic pool (Se-EMP) were defined to provide a quantitative assessment of selenium metabolism in these subjects. The initial 24-hr urine excretion of the label was higher for the intravenously administered label (18.2 +/- 2.1% of dose) compared to the oral dose (11.7 +/- 2.6% absorbed dose). Thereafter, the excretion of isotope was the same for both groups. For equivalent entry of Se into the body, measured total body retention and Se-EMP were the same for both groups. These initial kinetic data suggest that the overall utilization of selenium from a single administration of selenite is comparable for the two routes of intake and that the host's selenium requirement can probably be met adequately via the intravenous administration of selenite.
本研究的目的是探究单次给予的标记硒的去向，具体取决于其给药途径。因此，在两组（n = 4）健康年轻成年男性中，静脉注射或口服81.7微克剂量的74Se-亚硒酸盐后，通过中子活化分析测定血浆、尿液和粪便中作为74-Se-亚硒酸盐给予的稳定硒同位素的出现情况，这些男性的饮食中硒摄入量保持恒定且充足。根据这些同位素数据，定义了尿液排泄、全身潴留和亚硒酸盐可交换代谢池（Se-EMP）的可测量参数，以对这些受试者的硒代谢进行定量评估。静脉注射标记物的初始24小时尿液排泄量（占剂量的18.2 +/- 2.1%）高于口服剂量（吸收剂量的11.7 +/- 2.6%）。此后，两组的同位素排泄量相同。对于等量进入体内的硒，两组的测量全身潴留和Se-EMP相同。这些初始动力学数据表明，单次给予亚硒酸盐后，两种摄入途径对硒的总体利用率相当，并且通过静脉注射亚硒酸盐可能足以满足宿主的硒需求。
