Ducros V, Favier A, Guigues M
Laboratoire de Biochimie C, Hospital A. Michallon, Grenoble, France.
J Trace Elem Electrolytes Health Dis. 1991 Sep;5(3):145-54.
Many forms of selenium supplement are commercialized. The purpose of this work was to study the bioavailability of one selenium drug, "Granions de Sélénium", as compared with sodium selenite. Each product was labelled with enriched stable isotopes, and by means of gas chromatography/mass spectrometry (GC/MS), the metabolism of the two forms was followed simultaneously. In a first study, the absorption of a single dose of 480 micrograms Se (Na-Selenite) containing 100 micrograms of 74Se was compared with that of 480 micrograms Se (Granions) containing 100 micrograms of 76Se. Measurement precision was mediocre and only apparent absorption, urinary excretion and body retention could be measured. In a second experiment, kinetic studies were performed after a single oral dose of 100 micrograms of 74Se (Na-selenite) and 100 micrograms of 76Se (Granions). Blood, urine and feces samples were collected for a week to determine the true absorption, plasma half-life, and turnover of these two compounds. No significant difference in the metabolism of selenium was observed between "Granions de Sélénium" and selenite. Both present two maximal absorption peaks at 6 h and 12 h and a bioavailability of 76%.
多种形式的硒补充剂已商业化。这项工作的目的是研究一种硒药物“Granions de Sélénium”与亚硒酸钠相比的生物利用度。每种产品都用富集的稳定同位素进行了标记，并通过气相色谱/质谱联用仪（GC/MS）同时跟踪这两种形式的代谢情况。在第一项研究中，将含100微克74Se的480微克硒（亚硒酸钠）的单剂量吸收情况与含100微克76Se的480微克硒（Granions）的吸收情况进行了比较。测量精度一般，只能测量表观吸收、尿排泄和体内潴留情况。在第二项实验中，单次口服100微克74Se（亚硒酸钠）和100微克76Se（Granions）后进行了动力学研究。收集血液、尿液和粪便样本一周，以确定这两种化合物的真实吸收、血浆半衰期和周转率。未观察到“Granions de Sélénium”和亚硒酸盐在硒代谢方面有显著差异。两者在6小时和12小时均出现两个最大吸收峰，生物利用度均为76%。
