Sun Simo, Mizuno Yasuko, Komura Tomomi, Nishikawa Yoshikazu, Kage-Nakadai Eriko
Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
Biosci Microbiota Food Health. 2019;38(3):105-110. doi: 10.12938/bmfh.18-031. Epub 2019 May 23.
, a Gram-positive bacterium, is one of the commonly used probiotics. We previously showed that modified host defense systems and extended the lifespan of the nematode . In the present study, we showed that the lifespan extension caused by was enhanced in animals having a mutation in the gene that encodes the sole homolog of Toll-like receptors (TLRs). Meanwhile, lifespan increased by other probiotic bacteria, such as or , was not affected in the mutant animals. A microarray analysis revealed that the expression of innate immune response-related genes was significantly increased in the mutant. Worms with the mutation exhibited reduced leaving behavior from the lawn, while canonical downstream factors /TRAF and /IκB appeared to not be involved. In conclusion, /TLR regulates -induced longevity and also regulates behavior against .
革兰氏阳性菌 是常用的益生菌之一。我们之前表明， 改变了宿主防御系统并延长了线虫的寿命。在本研究中，我们发现，在编码Toll样受体（TLR）唯一同源物的 基因发生突变的动物中，由 引起的寿命延长得到增强。同时，其他益生菌，如 或 导致的寿命增加，在 突变动物中不受影响。微阵列分析显示，先天免疫反应相关基因的表达在 突变体中显著增加。具有 突变的线虫表现出从 菌苔离开的行为减少，而经典的下游因子 /TRAF和 /IκB似乎未参与其中。总之， /TLR调节 诱导的长寿，也调节对线虫的行为反应。
