• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大黄酚通过抑制细胞聚（ADP-核糖）化反应来预防阿霉素诱导的心脏毒性。

Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation.

作者信息

Lu Jing, Li Jingyan, Hu Yuehuai, Guo Zhen, Sun Duanping, Wang Panxia, Guo Kaiteng, Duan Dayue Darrel, Gao Si, Jiang Jianmin, Wang Junjian, Liu Peiqing

机构信息

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China.

出版信息

Acta Pharm Sin B. 2019 Jul;9(4):782-793. doi: 10.1016/j.apsb.2018.10.008. Epub 2018 Nov 1.

DOI:10.1016/j.apsb.2018.10.008
PMID:31384538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6663922/
Abstract

The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated from the rhizome of L., is considered to play a broad role in a variety of biological processes. However, the effects of CHR׳s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this study, we found that the cardiac apoptosis, mitochondrial injury and cellular PARylation levels were significantly increased in H9C2 cells treated by Dox, while these effects were suppressed by CHR. Similar results were observed when PARP1 activity was suppressed by its inhibitors 3-aminobenzamide (3AB) and ABT888. Ectopic expression of PARP1 effectively blocked this CHR׳s cardioprotection against DOX-induced cardiomyocyte injury in H9C2 cells. Furthermore, pre-administration with both CHR and 3AB relieved DOX-induced cardiac apoptosis, mitochondrial impairment and heart dysfunction in Sprague-Dawley rat model. These results revealed that CHR protects against DOX-induced cardiotoxicity by suppressing cellular PARylation and provided critical evidence that PARylation may be a novel target for DOX-induced cardiomyopathy.

摘要

阿霉素（DOX）在癌症化疗中的临床应用受到其危及生命的心脏毒性作用的限制。大黄酚（CHR）是从掌叶大黄根茎中分离出的一种蒽醌化合物，被认为在多种生物学过程中发挥广泛作用。然而，CHR对DOX诱导的心肌病的心脏保护作用尚不清楚。在本研究中，我们发现用DOX处理的H9C2细胞中心脏细胞凋亡、线粒体损伤和细胞PAR化水平显著增加，而CHR可抑制这些作用。当PARP1活性被其抑制剂3-氨基苯甲酰胺（3AB）和ABT888抑制时，也观察到了类似的结果。PARP1的异位表达有效地阻断了CHR对H9C2细胞中DOX诱导的心肌细胞损伤的心脏保护作用。此外，在Sprague-Dawley大鼠模型中，预先给予CHR和3AB可减轻DOX诱导的心脏细胞凋亡、线粒体损伤和心脏功能障碍。这些结果表明，CHR通过抑制细胞PAR化来保护心脏免受DOX诱导的毒性作用，并提供了关键证据，证明PAR化可能是DOX诱导的心肌病的一个新靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/ce88c9ecbebc/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/1d5b797b2275/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/85d4d3c625ee/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/4aae07427638/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/40e2cf6afeac/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/0a70fb76149d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/6abd883dc68f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/10b35017081d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/ce88c9ecbebc/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/1d5b797b2275/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/85d4d3c625ee/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/4aae07427638/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/40e2cf6afeac/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/0a70fb76149d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/6abd883dc68f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/10b35017081d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98d0/6663922/ce88c9ecbebc/gr7.jpg

相似文献

1
Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation.大黄酚通过抑制细胞聚（ADP-核糖）化反应来预防阿霉素诱导的心脏毒性。
Acta Pharm Sin B. 2019 Jul;9(4):782-793. doi: 10.1016/j.apsb.2018.10.008. Epub 2018 Nov 1.
2
Isorhapontigenin protects against doxorubicin-induced cardiotoxicity increasing YAP1 expression.异丹叶大黄素通过增加YAP1表达来预防阿霉素诱导的心脏毒性。
Acta Pharm Sin B. 2021 Mar;11(3):680-693. doi: 10.1016/j.apsb.2020.10.017. Epub 2020 Nov 1.
3
The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy.由PARP1介导的BRD4的多聚（ADP - 核糖基）化促进了病理性心脏肥大。
Acta Pharm Sin B. 2021 May;11(5):1286-1299. doi: 10.1016/j.apsb.2020.12.012. Epub 2020 Dec 14.
4
The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy.由PARP1介导的FoxO3多聚（ADP-核糖）化参与异丙肾上腺素诱导的心肌肥大。
Biochim Biophys Acta. 2016 Dec;1863(12):3027-3039. doi: 10.1016/j.bbamcr.2016.09.019.
5
Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity maintaining AMPK/UCP2 pathway.苦参碱通过维持AMPK/UCP2信号通路减轻阿霉素诱导的心脏毒性中的氧化应激和心肌细胞凋亡。
Acta Pharm Sin B. 2019 Jul;9(4):690-701. doi: 10.1016/j.apsb.2019.03.003. Epub 2019 Mar 16.
6
sFRP1 has a biphasic effect on doxorubicin-induced cardiotoxicity in a cellular location-dependent manner in NRCMs and Rats.sFRP1 以细胞位置依赖的方式对 NRCMs 和大鼠中的阿霉素诱导的心脏毒性具有双相作用。
Arch Toxicol. 2019 Feb;93(2):533-546. doi: 10.1007/s00204-018-2342-5. Epub 2018 Oct 30.
7
Periplocymarin Alleviates Doxorubicin-Induced Heart Failure and Excessive Accumulation of Ceramides.杠柳毒苷减轻阿霉素诱导的心力衰竭和神经酰胺过度蓄积。
Front Cardiovasc Med. 2021 Nov 19;8:732554. doi: 10.3389/fcvm.2021.732554. eCollection 2021.
8
Enhanced-autophagy by exenatide mitigates doxorubicin-induced cardiotoxicity.艾塞那肽增强自噬可减轻阿霉素诱导的心脏毒性。
Int J Cardiol. 2017 Apr 1;232:40-47. doi: 10.1016/j.ijcard.2017.01.123. Epub 2017 Jan 27.
9
Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting the Wnt/β-catenin signaling pathway.DKK1 通过抑制 Wnt/β-连环蛋白信号通路加重阿霉素诱导的心脏毒性。
J Cell Sci. 2019 May 16;132(10):jcs228478. doi: 10.1242/jcs.228478.
10
Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats.雄性自发性高血压心力衰竭（SHHF）、自发性高血压（SHR）和 Wistar Kyoto（WKY）大鼠慢性多柔比星治疗的心脏毒性差异。
Toxicol Appl Pharmacol. 2013 Nov 15;273(1):47-57. doi: 10.1016/j.taap.2013.08.012. Epub 2013 Aug 28.

引用本文的文献

1
Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity.针对阿霉素诱导的心脏毒性，以调节性细胞死亡为靶点的天然产物
Cell Death Discov. 2025 Mar 21;11(1):112. doi: 10.1038/s41420-025-02389-w.
2
Rhein Alleviates Doxorubicin-Induced Myocardial Injury by Inhibiting the p38 MAPK/HSP90/c-Jun/c-Fos Pathway-Mediated Apoptosis.瑞滨通过抑制 p38MAPK/HSP90/c-Jun/c-Fos 通路介导的细胞凋亡减轻多柔比星诱导的心肌损伤。
Cardiovasc Toxicol. 2024 Nov;24(11):1139-1150. doi: 10.1007/s12012-024-09917-7. Epub 2024 Sep 6.
3
Targeting Non-V600 Mutations in BRAF: A Single Institution Retrospective Analysis and Review of the Literature.

本文引用的文献

1
Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer.用于乳腺癌的聚乙烯吡咯烷酮/紫杉醇自组装体的研发
Acta Pharm Sin B. 2018 Jul;8(4):602-614. doi: 10.1016/j.apsb.2017.10.004. Epub 2017 Dec 10.
2
Synthesis of the novel PARP-1 inhibitor AG-690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling.新型PARP-1抑制剂AG-690/11026014的合成及其对血管紧张素II诱导的小鼠心脏重塑的保护作用。
Acta Pharmacol Sin. 2017 May;38(5):638-650. doi: 10.1038/aps.2016.159. Epub 2017 Feb 27.
3
The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration.
针对 BRAF 非 V600 突变：单机构回顾性分析和文献复习。
Drugs R D. 2024 Sep;24(3):395-403. doi: 10.1007/s40268-024-00475-5. Epub 2024 Aug 23.
4
Dual-Drug Loaded Nanobubbles Combined with Sonodynamic and Chemotherapy for Hepatocellular Carcinoma Therapy.载双药纳米气泡联合声动力与化学疗法治疗肝细胞癌。
Int J Nanomedicine. 2024 Jul 19;19:7367-7381. doi: 10.2147/IJN.S460329. eCollection 2024.
5
Incidence of chemotherapy-related cardiac dysfunction in cancer patients.癌症患者化疗相关性心功能障碍的发生率。
Clin Cardiol. 2024 Apr;47(4):e24269. doi: 10.1002/clc.24269.
6
Network Pharmacology along with Molecular Docking to Explore the Mechanism of Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome Validation.网络药理学结合分子对接探讨丹参注射液防治蒽环类药物心脏毒性的作用机制及转录组学验证。
Curr Pharm Des. 2024;30(12):952-967. doi: 10.2174/0113816128289845240305070522.
7
Study of the effect of bezafibrate with ginkgo biloba extracts in an animal model of hepatotoxicity induced by doxorubicin.在阿霉素诱导的肝毒性动物模型中，研究苯扎贝特与银杏叶提取物的联合作用。
Biochem Biophys Rep. 2023 Nov 21;36:101582. doi: 10.1016/j.bbrep.2023.101582. eCollection 2023 Dec.
8
Role of chemotherapeutic drugs in immunomodulation of cancer.化疗药物在癌症免疫调节中的作用。
Curr Res Immunol. 2023 Aug 31;4:100068. doi: 10.1016/j.crimmu.2023.100068. eCollection 2023.
9
Cardioprotective Effects of : A Review of Bioactive Extracts and Compounds.护心作用的研究进展：生物活性提取物和化合物的综述
J Evid Based Integr Med. 2023 Jan-Dec;28:2515690X231176622. doi: 10.1177/2515690X231176622.
10
JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit.JMJD6 通过去甲基化 p65 亚基的 R149 抑制 NF-κB 激活，从而防止异丙肾上腺素诱导的心肌肥厚。
Acta Pharmacol Sin. 2023 Sep;44(9):1777-1789. doi: 10.1038/s41401-023-01086-7. Epub 2023 Apr 25.
天然视网膜保护剂大黄素可减轻 N-甲基-N-亚硝脲诱导的视网膜变性小鼠模型中的光感受器细胞凋亡。
Sci Rep. 2017 Jan 23;7:41086. doi: 10.1038/srep41086.
4
Effects of a standardized extract of Rheum turkestanicum Janischew root on diabetic changes in the kidney, liver and heart of streptozotocin-induced diabetic rats.大黄素提取物对链脲佐菌素诱导的糖尿病大鼠肾脏、肝脏和心脏糖尿病变化的影响。
Biomed Pharmacother. 2017 Feb;86:605-611. doi: 10.1016/j.biopha.2016.12.059. Epub 2016 Dec 24.
5
The poly(ADP-ribosyl)ation of FoxO3 mediated by PARP1 participates in isoproterenol-induced cardiac hypertrophy.由PARP1介导的FoxO3多聚（ADP-核糖）化参与异丙肾上腺素诱导的心肌肥大。
Biochim Biophys Acta. 2016 Dec;1863(12):3027-3039. doi: 10.1016/j.bbamcr.2016.09.019.
6
Emodin and Its Role in Chronic Diseases.大黄素及其在慢性疾病中的作用。
Adv Exp Med Biol. 2016;928:47-73. doi: 10.1007/978-3-319-41334-1_3.
7
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.SIRT6通过激活自噬抑制异丙肾上腺素诱导的心肌肥大。
Transl Res. 2016 Jun;172:96-112.e6. doi: 10.1016/j.trsl.2016.03.002. Epub 2016 Mar 10.
8
Activating Peroxisome Proliferator-Activated Receptors (PPARs): a New Sight for Chrysophanol to Treat Paraquat-Induced Lung Injury.激活过氧化物酶体增殖物激活受体（PPARs）：大黄酚治疗百草枯诱导的肺损伤的新视角。
Inflammation. 2016 Apr;39(2):928-37. doi: 10.1007/s10753-016-0326-2.
9
P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice.P2X7作为大黄素治疗小鼠脂多糖诱导的抑郁症的新靶点。
Neurosci Lett. 2016 Feb 2;613:60-5. doi: 10.1016/j.neulet.2015.12.043. Epub 2015 Dec 24.
10
Doxorubicin causes transient activation of protein poly(ADP-ribosyl)ation in H9c2 cardiomyocytes.阿霉素可导致H9c2心肌细胞中蛋白质多聚（ADP - 核糖基）化的短暂激活。
Dokl Biochem Biophys. 2015;464:333-7. doi: 10.1134/S1607672915050178. Epub 2015 Oct 31.