Fadda Laila, Ali Hanaa M, Aldrees Ghada A, Alquraishi Noura M
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University Riyadh, Saudi Arabia.
Common First year Deanship, King Saud University, Riyadh, Saudi Arabia.
Toxicol Rep. 2019 Jul 22;6:712-717. doi: 10.1016/j.toxrep.2019.07.008. eCollection 2019.
Over doses of Paracetamol (panadol; acetaminophen) can cause life-threatening renal damage. This study compared the impact of nano-ubiquinone (Nubiq) with native ubiquinone (ubiq) reducing damage induced by Paracetamol-toxicity in rats. Paracetamol treatment produced an elevation in serum urea, uric acid, creatinine, C-reactive protein, renal nitric oxide, and lipid peroxide levels, and reductions in interleukin-10, superoxide dismutase, and glutathione levels. Meanwhile, c-Jun N-terminal kinases, vascular cell adhesion protein-1, cyclooxygenase-2 protein, and kidney injury molecule-1 were highly expressed, and NFE2-related factor 2 gene expression was down-regulated. Destruction of the epithelium, necrosis, and inflammatory cell infiltration could be observed in the renal tissue. Treatment with both ubiq an nubiq significantly ameliorated all of these signs. These findings suggest that Nubiq achieved the most significant amelioration in oxidative stress and inflammatory biomarkers in paracetamol -induced nephrotoxicity.
过量服用对乙酰氨基酚（必理通；醋氨酚）可导致危及生命的肾损伤。本研究比较了纳米泛醌（Nubiq）与天然泛醌（ubiq）对减轻大鼠对乙酰氨基酚毒性所致损伤的影响。对乙酰氨基酚治疗导致血清尿素、尿酸、肌酐、C反应蛋白、肾一氧化氮和脂质过氧化物水平升高，白细胞介素-10、超氧化物歧化酶和谷胱甘肽水平降低。同时，c-Jun氨基末端激酶、血管细胞黏附蛋白-1、环氧化酶-2蛋白和肾损伤分子-1高表达，而NFE2相关因子2基因表达下调。在肾组织中可观察到上皮破坏、坏死和炎性细胞浸润。用ubiq和Nubiq治疗均显著改善了所有这些症状。这些发现表明，Nubiq在对乙酰氨基酚诱导的肾毒性中对氧化应激和炎性生物标志物的改善最为显著。
