Mohamad Sakinah, Hamid Suzina Sheikh Ab, Azlina Ahmad, Md Shukri Norasnieda
Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Basic Science and Oral Biology Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Asia Pac Allergy. 2019 Jul 8;9(3):e22. doi: 10.5415/apallergy.2019.9.e22. eCollection 2019 Jul.
Chronic rhinosinusitis (CRS) is one of the most common and complex chronic inflammatory disease of sinonasal mucosa. Even though the pathogenesis of CRS is multifactorial and still unclear, the role of cytokines especially interleukin-1 (IL-1) is being investigated worldwide in different population because of varying results obtained.
To study the association of ( and ) gene polymorphisms with chronic rhinosinusitis with nasal polyp (CRSwNP) and without nasal polyp (CRSsNP), and other factors related.
This is a case-controlled study which include a total of 138 subjects recruited from Otorhinolaryngology-Head and Neck Surgery clinic in Hospital Universiti Sains Malaysia. Genotyping of the (+4845G, +4845T) and (-511C, -511T) were performed with restriction fragment length polymorphism analysis.
There was a statistical significant association between (-511C, -511T) polymorphism with CRSwNP and CRSsNP ( < 0.001). The CT genotype of was markedly increased in CRSwNP subjects (52.2%). However, there was no significant association found between (+4845G, +4845T) with CRSwNP and CRSsNP ( = 0.093). No association was found in factors related to CRS, which included asthma, atopy, allergy, aspirin sensitivity, and family history of nasal polyp ( value of 0.382, 0.382, 0.144, >0.95, and 0.254, respectively).
This study indicates an association of (-511C, -511T) polymorphism with CRSwNP and CRSsNP in our population, hence there is a possibility of involvement in modulating pathogenesis of CRS. There was no significant association of (+4845G, +4845T) polymorphism with CRSwNP and CRSsNP, and other factors related.
慢性鼻-鼻窦炎（CRS）是鼻窦黏膜最常见且复杂的慢性炎症性疾病之一。尽管CRS的发病机制是多因素的且仍不明确，但由于研究结果各异，细胞因子尤其是白细胞介素-1（IL-1）在世界各地不同人群中的作用正在被研究。
研究（和）基因多态性与伴鼻息肉慢性鼻-鼻窦炎（CRSwNP）和不伴鼻息肉慢性鼻-鼻窦炎（CRSsNP）以及其他相关因素之间的关联。
这是一项病例对照研究，共纳入138名受试者，均来自马来西亚理科大学医院耳鼻喉头颈外科门诊。采用限制性片段长度多态性分析对（+4845G，+4845T）和（-511C，-511T）进行基因分型。
（-511C，-511T）多态性与CRSwNP和CRSsNP之间存在统计学显著关联（<0.001）。CRSwNP受试者中（的）CT基因型显著增加（52.2%）。然而，（+4845G，+4845T）与CRSwNP和CRSsNP之间未发现显著关联（=0.093）。在与CRS相关的因素中未发现关联，这些因素包括哮喘、特应性、过敏、阿司匹林敏感性和鼻息肉家族史（分别为0.382、0.382、0.144、>0.95和0.254）。
本研究表明在我们的人群中（-511C，-511T）多态性与CRSwNP和CRSsNP相关，因此有可能参与调节CRS的发病机制。（+4845G，+4845T）多态性与CRSwNP和CRSsNP以及其他相关因素之间未发现显著关联。
