Association of gene polymorphisms with chronic rhinosinusitis with and without nasal polyp.

BACKGROUND

Chronic rhinosinusitis (CRS) is one of the most common and complex chronic inflammatory disease of sinonasal mucosa. Even though the pathogenesis of CRS is multifactorial and still unclear, the role of cytokines especially interleukin-1 (IL-1) is being investigated worldwide in different population because of varying results obtained.

OBJECTIVE

To study the association of ( and ) gene polymorphisms with chronic rhinosinusitis with nasal polyp (CRSwNP) and without nasal polyp (CRSsNP), and other factors related.

METHODS

This is a case-controlled study which include a total of 138 subjects recruited from Otorhinolaryngology-Head and Neck Surgery clinic in Hospital Universiti Sains Malaysia. Genotyping of the (+4845G, +4845T) and (-511C, -511T) were performed with restriction fragment length polymorphism analysis.

RESULTS

There was a statistical significant association between (-511C, -511T) polymorphism with CRSwNP and CRSsNP ( < 0.001). The CT genotype of was markedly increased in CRSwNP subjects (52.2%). However, there was no significant association found between (+4845G, +4845T) with CRSwNP and CRSsNP ( = 0.093). No association was found in factors related to CRS, which included asthma, atopy, allergy, aspirin sensitivity, and family history of nasal polyp ( value of 0.382, 0.382, 0.144, >0.95, and 0.254, respectively).

CONCLUSION

This study indicates an association of (-511C, -511T) polymorphism with CRSwNP and CRSsNP in our population, hence there is a possibility of involvement in modulating pathogenesis of CRS. There was no significant association of (+4845G, +4845T) polymorphism with CRSwNP and CRSsNP, and other factors related.