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慢性鼻-鼻窦炎中肿瘤坏死因子α -1031和肿瘤坏死因子β +252单核苷酸多态性的研究

A Study of Single Nucleotide Polymorphisms of Tumour Necrosis Factor α-1031 And Tumour Necrosis Factor β+ 252 in Chronic Rhinosinusitis.

作者信息

Misron Khairunnisak, Hamid Suzina Sheikh Ab, Ahmad Azlina, Ramli Ramiza Ramza

机构信息

Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia.

Basic Science and Oral Biology Unit, School of Dental Sciences, Universiti Sains Malaysia Health Campus, Kelantan, Malaysia.

出版信息

Clin Exp Otorhinolaryngol. 2017 Sep;10(3):241-247. doi: 10.21053/ceo.2016.01732. Epub 2017 Apr 28.

DOI:10.21053/ceo.2016.01732
PMID:28449554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5545697/
Abstract

OBJECTIVES

This case-controlled study aimed to identify the association of tumor necrosis factor ()- and + gene polymorphisms between chronic rhinosinusitis (CRS) and healthy controls. Another purpose of this study was to investigate the associations of these gene polymorphisms with factors related to CRS.

METHODS

All deoxyribonucleic acid (DNA) samples were genotyped for and genes by mean of polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP). The statistical analysis were carried out using chi-square test or Fisher exact test to determine the associations of these gene polymorphisms in CRS. Multiple logistic regression was performed to evaluate the associations of these gene polymorphisms in CRS and its related risk factors.

RESULTS

The genotype and allele frequencies of and gene did not show any significant associations between CRS and healthy controls. However, a significantly statistical difference of was observed in CRS participants with atopy (-value, 0.045; odds ratio, 3.66) but not in CRS with asthma or aspirin intolerance.

CONCLUSION

Although the presence of and gene polymorphisms did not render any significant associations between CRS and healthy control, this study suggests that gene polymorphisms in CRS patients with atopy may be associated with increase susceptibility towards CRS.

摘要

目的

本病例对照研究旨在确定慢性鼻 - 鼻窦炎（CRS）与健康对照之间肿瘤坏死因子（）- 和 + 基因多态性的关联。本研究的另一个目的是调查这些基因多态性与CRS相关因素的关联。

方法

所有脱氧核糖核酸（DNA）样本通过聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）方法对 和 基因进行基因分型。使用卡方检验或Fisher精确检验进行统计分析，以确定这些基因多态性在CRS中的关联。进行多因素逻辑回归以评估这些基因多态性在CRS及其相关危险因素中的关联。

结果

和 基因的基因型和等位基因频率在CRS与健康对照之间未显示出任何显著关联。然而，在患有特应性的CRS参与者中观察到 存在显著统计学差异（P值，0.045；比值比，3.66），但在患有哮喘或阿司匹林不耐受的CRS患者中未观察到。

结论

尽管 和 基因多态性的存在在CRS与健康对照之间未产生任何显著关联，但本研究表明，患有特应性的CRS患者中的 基因多态性可能与CRS易感性增加有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e8/5545697/5a4bbb036d93/ceo-2016-01732f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e8/5545697/1077b1efcf8e/ceo-2016-01732f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e8/5545697/5a4bbb036d93/ceo-2016-01732f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e8/5545697/1077b1efcf8e/ceo-2016-01732f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58e8/5545697/5a4bbb036d93/ceo-2016-01732f2.jpg

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