A Study of Single Nucleotide Polymorphisms of Tumour Necrosis Factor α-1031 And Tumour Necrosis Factor β+ 252 in Chronic Rhinosinusitis.

OBJECTIVES

This case-controlled study aimed to identify the association of tumor necrosis factor ()- and + gene polymorphisms between chronic rhinosinusitis (CRS) and healthy controls. Another purpose of this study was to investigate the associations of these gene polymorphisms with factors related to CRS.

METHODS

All deoxyribonucleic acid (DNA) samples were genotyped for and genes by mean of polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP). The statistical analysis were carried out using chi-square test or Fisher exact test to determine the associations of these gene polymorphisms in CRS. Multiple logistic regression was performed to evaluate the associations of these gene polymorphisms in CRS and its related risk factors.

RESULTS

The genotype and allele frequencies of and gene did not show any significant associations between CRS and healthy controls. However, a significantly statistical difference of was observed in CRS participants with atopy (-value, 0.045; odds ratio, 3.66) but not in CRS with asthma or aspirin intolerance.

CONCLUSION

Although the presence of and gene polymorphisms did not render any significant associations between CRS and healthy control, this study suggests that gene polymorphisms in CRS patients with atopy may be associated with increase susceptibility towards CRS.