Too Joan Jue Ying, Shek Lynette Pei-Chi, Rajakulendran Mohana
Yong Loo Lin School of Medicine National University of Singapore, Singapore.
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Asia Pac Allergy. 2019 Jul 12;9(3):e25. doi: 10.5415/apallergy.2019.9.e25. eCollection 2019 Jul.
The Pink peppercorn belongs to the same Anacardiaceae family as cashew and pistachio. However, the cross-reactivity of pink peppercorn with cashew and pistachio has yet to be studied. To date, there has been a single case report of anaphylaxis to pink peppercorn in a cashew and pistachio allergic individual.
We aim to demonstrate cross-sensitization to pink peppercorn in cashew and/or pistachio allergic children.
A small descriptive cohort study looking at cross-sensitization of pink peppercorn in cashew and/or pistachio allergic children was conducted. Children with a history of reaction to pistachio and/or cashew nut underwent skin prick tests to the pink peppercorn species to determine cross-sensitization.
Out of the 21 cashew and/or pistachio allergic subjects, 16 (76.2%) demonstrated cross-sensitization to pink peppercorn. None of the subjects had any knowledge of previous exposure or allergic reactions to pink peppercorn.
This study demonstrates potential cross-reactivity between pink peppercorn and cashew and pistachio. While an oral food challenge to pink peppercorn would have been important in demonstrating clinical cross-reactivity, this was not performed due to ethical constraints. We hope to increase the awareness of pink peppercorn as a potential and hidden source of allergen and encourage further studies to demonstrate the clinical cross-reactivity and to better delineate the major allergen involved.
粉红胡椒与腰果和开心果属于同一漆树科。然而，粉红胡椒与腰果和开心果之间的交叉反应性尚未得到研究。迄今为止，仅有一例对腰果和开心果过敏的个体发生粉红胡椒过敏反应的病例报告。
我们旨在证明对腰果和/或开心果过敏的儿童对粉红胡椒存在交叉致敏反应。
开展了一项小型描述性队列研究，观察对腰果和/或开心果过敏的儿童对粉红胡椒的交叉致敏反应。有开心果和/或腰果过敏反应史的儿童接受了针对粉红胡椒品种的皮肤点刺试验，以确定交叉致敏反应。
在21名对腰果和/或开心果过敏的受试者中，16名（76.2%）表现出对粉红胡椒的交叉致敏反应。所有受试者均不知道之前曾接触过粉红胡椒或对其有过敏反应。
本研究证明了粉红胡椒与腰果和开心果之间可能存在交叉反应性。虽然对粉红胡椒进行口服食物激发试验对于证明临床交叉反应性很重要，但由于伦理限制未进行此项试验。我们希望提高人们对粉红胡椒作为一种潜在的隐藏过敏原来源的认识，并鼓励进一步开展研究以证明临床交叉反应性，并更好地确定所涉及的主要过敏原。
