Zand Vahid, Baradaranfar Mohammadhossein, Dadgarnia Mohammadhossein, Meybodian Mojtaba, Vaziribozorg Sedighe, Mandegari Mohammad, Behniafard Nasrin, Dehghani Amrollah
Department of Otolaryngology- Head and Neck Surgery , Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Allergy and Clinical Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Iran J Otorhinolaryngol. 2019 Jul;31(105):203-208.
This study evaluated the effect of gelfoam impregnated with botulinum toxin on the symptoms induced by allergic rhinitis.
In total, 30 patients with allergic rhinitis who did not respond to common therapies were included in this clinical trial study. All patients were treated with intranasal gelfoam impregnated with botulinum toxin type a (40 unit in each side) placed in the middle meatus of each nostril. The main symptoms of allergic rhinitis were scored from zero to three by the patients. Symptoms recorded and compared before and two months after the treatment.
The mean age of patients was 31.03±6.9 years. The mean score for sneezing was 2.23 before the treatment which significantly decreased to 1.06 after the treatment (P<0.05). The mean scores of rhinorrhea, nasal congestion, and nasal itching were 2.53, 2.03, and 1.93, respectively, before the treatment which significantly decreased to 0.93, 1, and 0.8 after the treatment (P<0.05). No reported side effects was observed in this study.
According to the results, treatment with gelfoam impregnated with botulinum toxin is an effective and safe method in patients who have not responded to common therapies for allergic rhinitis. Accordingly, it is recommended to relieve symptoms in patients with seasonal allergic rhinitis in order to maintain the effectiveness of this treatment at least 8 weeks.
本研究评估了含肉毒杆菌毒素的明胶海绵对变应性鼻炎所致症状的影响。
本临床试验研究共纳入30例对常规治疗无反应的变应性鼻炎患者。所有患者均接受在每个鼻孔中鼻道放置含A型肉毒杆菌毒素的鼻内明胶海绵治疗（每侧40单位）。变应性鼻炎的主要症状由患者从0至3进行评分。记录并比较治疗前及治疗后两个月的症状。
患者的平均年龄为31.03±6.9岁。治疗前打喷嚏的平均评分为2.23，治疗后显著降至1.06（P<0.05）。治疗前流涕、鼻塞和鼻痒的平均评分分别为2.53、2.03和1.93，治疗后显著降至0.93、1和0.8（P<0.05）。本研究中未观察到报告的副作用。
根据结果，对于对变应性鼻炎常规治疗无反应的患者，用含肉毒杆菌毒素的明胶海绵治疗是一种有效且安全的方法。因此，建议缓解季节性变应性鼻炎患者的症状，以便至少在8周内维持该治疗的有效性。
