Bajju Gauri Devi, Ahmed Altaf, Devi Gita
Department of Chemistry, University of Jammu, New Campus, Baba Sahib Ambedkar Road, Jammu, Jammu and Kashmir 180 006 India.
BMC Chem. 2019 Feb 4;13(1):15. doi: 10.1186/s13065-019-0523-9. eCollection 2019 Dec.
Herein, we report the synthesis of metal complexes of vanadium with heterocyclic tetradentate ligand. Four N atoms of the heterocyclic porphyrin ring occupy the equatorial position and O atom of salicylic acid occupies the axial position in the complex. The thermal and chemical stability of the complexes were assessed by thermogravimetric analysis (TGA). The electrochemical behavior of the designed complexes is also studied using cyclic voltammetry. These complexes were then further evaluated for in vitro anticancer effects, anti-oxidant and behavior during acute toxicity of the synthesized porphyrin ligands and their oxovanadium(IV) complexes. The interaction of these metal complexes with radical scavenger 2,2-diphenyl-1-picrylhydrazyl (DPPH), encouraged us to study the anti-oxidant behavior of such complexes. The complex (SSA)VO(TMP) i.e. oxovanadium(IV)tetra(4-methoxyphenyl)porphyrinsulphosalicylate showed in vitro cytotoxic activity against glioblastoma (T986). It would be pertinent to mention here that the complex also did not exhibit any adverse toxicological symptoms and mortality in the target animal at the limit test dose level of 2000 mg/kg body weight.
在此，我们报道了钒与杂环四齿配体金属配合物的合成。杂环卟啉环的四个氮原子占据配合物的赤道位置，水杨酸的氧原子占据轴向位置。通过热重分析（TGA）评估了配合物的热稳定性和化学稳定性。还使用循环伏安法研究了所设计配合物的电化学行为。然后进一步评估了这些配合物对合成卟啉配体及其氧钒（IV）配合物的体外抗癌作用、抗氧化作用和急性毒性行为。这些金属配合物与自由基清除剂2,2-二苯基-1-苦基肼（DPPH）的相互作用促使我们研究此类配合物的抗氧化行为。配合物（SSA）VO（TMP），即氧钒（IV）四（4-甲氧基苯基）卟啉磺基水杨酸盐，对胶质母细胞瘤（T986）显示出体外细胞毒性活性。在此值得一提的是，在2000mg/kg体重的极限试验剂量水平下，该配合物在目标动物中也未表现出任何不良毒理学症状和死亡率。
