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细胞治疗继发性淋巴水肿的临床前和临床研究综述。

Review of preclinical and clinical studies of using cell-based therapy for secondary lymphedema.

机构信息

Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Department of Surgery, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

出版信息

J Surg Oncol. 2020 Jan;121(1):109-120. doi: 10.1002/jso.25661. Epub 2019 Aug 5.

DOI:10.1002/jso.25661
PMID:31385308
Abstract

Secondary lymphedema is associated with impaired lymph fluid drainage and remains incurable. Alternatively, cell-based therapy may pave the way for lymphedema treatment. We found 11 animal and seven human studies had been conducted from 2008 to 2018. Most studies showed great potential for this treatment modality. Emerging studies have focused on novel techniques, such as coupling cell therapy with lymph node transfer, or adding growth factors to cell therapy.

摘要

继发性淋巴水肿与淋巴液引流受损有关,目前仍然无法治愈。相反,基于细胞的治疗方法可能为淋巴水肿的治疗开辟道路。我们发现,从 2008 年到 2018 年,已经进行了 11 项动物研究和 7 项人体研究。大多数研究表明这种治疗方式具有巨大的潜力。新兴的研究集中在新的技术上,如将细胞治疗与淋巴结转移相结合,或在细胞治疗中添加生长因子。

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