CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, P.R. China.
Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui, 230026, P.R. China.
Chemistry. 2019 Oct 1;25(55):12789-12794. doi: 10.1002/chem.201902434. Epub 2019 Sep 9.
Ruthenium-arene complexes are a unique class of organometallic compounds that have been shown to have prominent therapeutic potencies. Here, we have investigated the interactions of Ru-cymene complexes with a zinc-finger protein NCp7, aiming to understand the effects of various ligands on the reaction. Five different binding modes were observed on selected Ru-complexes. Ru-cymene complex can bind to proteins through either noncovalent binding alone or through a combination of covalent and noncovalent binding modes. Moreover, the noncovalent interaction can promote the coordination of Ru to NCp7, resulting synergistic effects of the different ligands. The binding of Ru(Cym) complexes leads to dysfunction of NCp7 through zinc-ejection and structural perturbation. These results indicate that the reactivity of Ru-complexes can be modulated by ligands through different approaches, which could be closely correlated to their different therapeutic effects.
钌芳烃配合物是一类独特的有机金属化合物，已被证明具有显著的治疗功效。在这里，我们研究了 Ru-柠檬烯配合物与锌指蛋白 NCp7 的相互作用，旨在了解不同配体对反应的影响。在选定的 Ru-配合物上观察到了五种不同的结合模式。Ru-柠檬烯配合物可以通过非共价键单独结合或通过共价和非共价键结合模式的组合与蛋白质结合。此外，非共价相互作用可以促进 Ru 与 NCp7 的配位，从而产生不同配体的协同效应。Ru(Cym) 配合物的结合导致 NCp7 通过锌喷射和结构扰动而功能失调。这些结果表明，配体可以通过不同的方法来调节 Ru-配合物的反应性，这可能与其不同的治疗效果密切相关。
