卵巢刺激方式在反应不良者中的应用。
Ovarian stimulation modalities in poor responders.
机构信息
Department of Obstetrics and Gynecology, School of Medicine, Kırıkkale University, Kırıkkale, Turkey
出版信息
Turk J Med Sci. 2019 Aug 8;49(4):959-962. doi: 10.3906/sag-1905-179.
Abstract
In a group of IVF/ICSI cycles, despite the appropriate ovarian stimulation, the number of oocytes collected is below the expected value. This condition is defined as poor ovarian response (POR) to stimulation. POR brings the risk of cycle cancellation with an estimated rate of 20%. Infertility experts are trying to improve cycle outcomes of POR cases with multiple modifications. This review article will present the latest modifications on the management of POR. The studies performed for improving cycle outcome in POR cases were evaluated and their notable results were presented. The first intervention among infertility specialists is to make a standard definition for POR. The BOLOGNA criteria and the subsequent POSEIDON group definitions are the latest updates in POR management. GnRH antagonists, estradiol priming, double stimulation, letrozole administration, DHEA, and herbal therapy supplementations are the recent modifications done to improve oocyte retrieval and subsequent embryo transfer for POR cases. This review article presents the encouraging methods applied for POR cases to improve cycle outcome.
摘要
在一组体外受精/卵胞浆内单精子注射（IVF/ICSI）周期中，尽管进行了适当的卵巢刺激，但采集的卵母细胞数量低于预期。这种情况被定义为卵巢刺激反应不良（POR）。POR 带来了取消周期的风险，估计发生率为 20%。不孕专家正在尝试通过多种改良来改善 POR 病例的周期结局。本文将介绍 POR 管理的最新改良措施。评估了为改善 POR 病例的周期结局而进行的研究，并介绍了其显著结果。不孕专家的第一步干预措施是为 POR 制定标准定义。BOLOGNA 标准和随后的 POSEIDON 组定义是 POR 管理的最新更新。GnRH 拮抗剂、雌二醇预处理、双重刺激、来曲唑给药、DHEA 和草药疗法补充剂是为改善 POR 病例的卵母细胞采集和随后的胚胎移植而进行的最新改良措施。本文介绍了为改善 POR 病例的周期结局而应用的令人鼓舞的方法。
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