Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
The Fertility Clinic Skive Regional Hospital, 7800 Skive, Denmark.
Int J Mol Sci. 2020 Mar 19;21(6):2110. doi: 10.3390/ijms21062110.
Poor ovarian response (POR) to controlled ovarian stimulation (OS) presents a major challenge in assisted reproduction. The Bologna criteria represented the first serious attempt to set clear criteria for the definition of POR. However, the Bologna criteria were questioned because of the persistent heterogeneity among POR patients and the inability to provide management strategies. Based on these facts, a more recent classification, the POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) classification, was developed to provide a homogeneous and refined definition of POR that significantly reduces the heterogeneity of the Bologna criteria definition of POR and helps in the clinical handling and counseling of patients. In this review, we discuss the impact of the POSEIDON classification on the clinical management of patients with POR.
卵巢反应不良（POR）对控制性卵巢刺激（COS）是辅助生殖的主要挑战。博洛尼亚标准是首次尝试为 POR 的定义制定明确标准。然而，由于 POR 患者之间持续存在异质性，以及无法提供管理策略，博洛尼亚标准受到了质疑。基于这些事实，最近开发了一种更具针对性的分类方法，即 POSEIDON（以患者为中心的涵盖个体化卵母细胞数的策略）分类，旨在提供 POR 的同质和精细定义，显著减少了博洛尼亚标准定义的 POR 异质性，并有助于 POR 患者的临床处理和咨询。在这篇综述中，我们讨论了 POSEIDON 分类对 POR 患者临床管理的影响。
