• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

母亲孕期饮酒与早产风险的关联：日本环境与儿童研究。

Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study.

机构信息

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita-shi, Japan.

Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

出版信息

BJOG. 2019 Nov;126(12):1448-1454. doi: 10.1111/1471-0528.15899. Epub 2019 Aug 25.

DOI:10.1111/1471-0528.15899
PMID:31386246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7003893/
Abstract

OBJECTIVE

To examine the association between maternal alcohol consumption during pregnancy and the risk of preterm delivery.

DESIGN

Prospective cohort study.

SETTING

The Japan Environment and Children's Study (JECS).

POPULATION

A total of 94 349 singleton pregnancies.

METHODS

Participants completed questionnaires detailing alcohol consumption during the first trimester and during the second and third trimesters. Participants were divided into four categories according to alcohol consumption (non-drinkers, consumers of 1-149 g, 150-299 g and ≥300 g ethanol/week). We examined the effect of alcohol consumption during different stages of pregnancy on the risk of preterm delivery. Odds ratios (OR) and 95% CI were calculated relative to non-drinkers using logistic regression.

MAIN OUTCOME MEASURES

Medical record-based preterm delivery.

RESULTS

Alcohol consumption during the second and third trimesters, but not during the first trimester, was associated with increased risk of preterm delivery. Heavy alcohol consumption (≥300 g ethanol/week) during the second and third trimesters was associated with a four-fold higher risk compared with non-drinkers (multivariable OR 4.52; 95% CI 1.68-12.2). Light alcohol consumption (1-149 g ethanol/week) tended to be associated with lower risk of preterm delivery (multivariable OR 0.78; 95% CI 0.60-1.00).

CONCLUSIONS

Heavy alcohol consumption during the second and third trimesters was associated with increased risk of preterm delivery among pregnant women.

TWEETABLE ABSTRACT

Heavy drinking during pregnancy may increase the risk of preterm delivery.

摘要

目的

探讨孕期母亲饮酒与早产风险的关系。

设计

前瞻性队列研究。

地点

日本环境与儿童研究（JECS）。

人群

共纳入 94349 例单胎妊娠。

方法

参与者完成了详细的问卷，内容包括妊娠早期和妊娠第二、第三阶段的饮酒情况。参与者根据饮酒量（不饮酒者、每周饮酒 1-149g、150-299g 和≥300g 乙醇）分为四组。我们研究了妊娠不同阶段饮酒对早产风险的影响。使用逻辑回归计算相对于不饮酒者的比值比（OR）和 95%置信区间（CI）。

主要结局指标

基于医疗记录的早产。

结果

妊娠第二和第三阶段的饮酒与早产风险增加相关，而妊娠第一阶段的饮酒与早产风险增加无关。与不饮酒者相比，妊娠第二和第三阶段大量饮酒（≥300g 乙醇/周）的早产风险增加了四倍（多变量 OR 4.52；95%CI 1.68-12.2）。轻度饮酒（每周 1-149g 乙醇）与早产风险降低相关（多变量 OR 0.78；95%CI 0.60-1.00）。

结论

妊娠第二和第三阶段大量饮酒与孕妇早产风险增加相关。

推文摘要

孕期大量饮酒可能增加早产风险。

相似文献

1
Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study.母亲孕期饮酒与早产风险的关联：日本环境与儿童研究。
BJOG. 2019 Nov;126(12):1448-1454. doi: 10.1111/1471-0528.15899. Epub 2019 Aug 25.
2
Effects of physical activity during pregnancy on preterm delivery and mode of delivery: The Japan Environment and Children's Study, birth cohort study.孕期身体活动对早产和分娩方式的影响：日本环境与儿童研究，出生队列研究。
PLoS One. 2018 Oct 29;13(10):e0206160. doi: 10.1371/journal.pone.0206160. eCollection 2018.
3
The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS).孕妇全血重金属浓度与早产的关系：日本环境与儿童研究（JECS）。
Environ Res. 2018 Oct;166:562-569. doi: 10.1016/j.envres.2018.06.025. Epub 2018 Jun 28.
4
The effect of maternal alcohol consumption on fetal growth and preterm birth.母亲饮酒对胎儿生长和早产的影响。
BJOG. 2009 Feb;116(3):390-400. doi: 10.1111/j.1471-0528.2008.02058.x.
5
Alcohol consumption during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study.孕期饮酒与出生结局：九州冲绳母婴健康研究
BMC Pregnancy Childbirth. 2014 Feb 20;14:79. doi: 10.1186/1471-2393-14-79.
6
Maternal triglyceride levels and neonatal outcomes: The Japan Environment and Children's Study.母亲甘油三酯水平与新生儿结局：日本环境与儿童健康研究。
J Clin Lipidol. 2023 May-Jun;17(3):356-366. doi: 10.1016/j.jacl.2023.04.005. Epub 2023 Apr 21.
7
Impact of stage 1 hypertension in the first and second trimesters on adverse pregnancy outcomes: The Japan Environment and Children's study (JECS).第一和第二孕期 1 期高血压对不良妊娠结局的影响：日本环境与儿童研究（JECS）。
Pregnancy Hypertens. 2022 Dec;30:232-237. doi: 10.1016/j.preghy.2022.11.002. Epub 2022 Nov 14.
8
Maternal alcohol intake prior to and during pregnancy and risk of adverse birth outcomes: evidence from a British cohort.孕期及孕前母亲饮酒与不良分娩结局风险：来自英国队列的证据
J Epidemiol Community Health. 2014 Jun;68(6):542-9. doi: 10.1136/jech-2013-202934. Epub 2014 Mar 10.
9
Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study.低至中度孕期饮酒与特定出生结局风险：一项前瞻性队列研究。
Ann Epidemiol. 2015 Jan;25(1):46-54.e3. doi: 10.1016/j.annepidem.2014.10.011. Epub 2014 Oct 16.
10
Modifying the risk of recurrent preterm birth: influence of trimester-specific changes in smoking behaviors.改变复发性早产风险：吸烟行为在各孕期的变化的影响。
Am J Obstet Gynecol. 2017 Mar;216(3):310.e1-310.e8. doi: 10.1016/j.ajog.2016.11.1034. Epub 2016 Nov 18.

引用本文的文献

1
Sequelae of preterm birth over the lifespan: an exploratory analysis of behavioral problems in childhood and increased risk of major depression and anxiety in adulthood from a cohort study.早产对一生的后遗症：一项队列研究对儿童期行为问题以及成年期重度抑郁和焦虑风险增加的探索性分析。
EClinicalMedicine. 2025 Jul 8;85:103316. doi: 10.1016/j.eclinm.2025.103316. eCollection 2025 Jul.
2
Gestational Age and Cognitive Development in Childhood.胎龄与儿童期认知发展
JAMA Netw Open. 2025 Apr 1;8(4):e254580. doi: 10.1001/jamanetworkopen.2025.4580.
3
Environmental Exposure to Per- and Polyfluorylalkyl Substances (PFASs) and Reproductive Outcomes in the General Population: A Systematic Review of Epidemiological Studies.

本文引用的文献

1
Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study.日本孕期饮酒与妊娠高血压疾病的关系：日本环境与儿童研究。
Hypertens Res. 2019 Jan;42(1):85-94. doi: 10.1038/s41440-018-0124-3. Epub 2018 Nov 7.
2
Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis.ALDH2 和 ADH1B 多态性、饮酒与胃癌的关系：一项复制和中介分析。
Gastric Cancer. 2018 Nov;21(6):936-945. doi: 10.1007/s10120-018-0823-0. Epub 2018 Apr 3.
3
Baseline Profile of Participants in the Japan Environment and Children's Study (JECS).
一般人群中环境暴露于全氟和多氟烷基物质（PFASs）与生殖结局的关系：流行病学研究的系统评价
Int J Environ Res Public Health. 2024 Dec 2;21(12):1615. doi: 10.3390/ijerph21121615.
4
Association between antinuclear antibodies status and preterm birth in Japanese pregnant women: a prospective cohort study from Adjunct Study of the Japan Environment and Children's Study.日本孕妇抗核抗体状态与早产之间的关联：来自日本环境与儿童研究附属研究的一项前瞻性队列研究
BMC Pregnancy Childbirth. 2024 Dec 28;24(1):879. doi: 10.1186/s12884-024-07084-9.
5
Magnitude and risk factors of khat, alcohol and cigarettes use among pregnant women in Africa: a systematic review and meta-analysis.非洲孕妇使用阿拉伯茶、酒精和香烟的程度和风险因素：系统评价和荟萃分析。
BMC Pregnancy Childbirth. 2024 Nov 27;24(1):795. doi: 10.1186/s12884-024-06999-7.
6
Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor.早产的早期诊断与治疗的最新进展和挑战
Bioengineering (Basel). 2024 Feb 6;11(2):161. doi: 10.3390/bioengineering11020161.
7
Genetic susceptibility for retinopathy of prematurity and its associated comorbidities.早产儿视网膜病变及其相关合并症的遗传易感性。
Pediatr Res. 2024 Oct;96(5):1325-1331. doi: 10.1038/s41390-024-03068-9. Epub 2024 Feb 12.
8
Prevalence and factors associated with preterm birth in a rural district hospital, Rwanda.卢旺达农村地区医院早产的患病率及相关因素。
Pan Afr Med J. 2022 Dec 5;43:173. doi: 10.11604/pamj.2022.43.173.34113. eCollection 2022.
9
New Validated Short Questionnaire for the Evaluation of the Adherence of Mediterranean Diet and Nutritional Sustainability in All Adult Population Groups.适用于所有成年人群组的地中海饮食依从性和营养可持续性评估新的经过验证的简短问卷
Nutrients. 2022 Dec 5;14(23):5177. doi: 10.3390/nu14235177.
10
Nationwide-free preconception care strategy: Experience from China.全国免费孕前保健策略：中国的经验。
Front Public Health. 2022 Oct 19;10:934983. doi: 10.3389/fpubh.2022.934983. eCollection 2022.
日本环境与儿童研究（JECS）参与者的基线特征。
J Epidemiol. 2018 Feb 5;28(2):99-104. doi: 10.2188/jea.JE20170018. Epub 2017 Oct 25.
4
Sensitivity Analysis in Observational Research: Introducing the E-Value.观察性研究中的敏感性分析：引入 E 值。
Ann Intern Med. 2017 Aug 15;167(4):268-274. doi: 10.7326/M16-2607. Epub 2017 Jul 11.
5
Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area.在日本公共卫生中心下一代前瞻性研究（JPHC-NEXT）方案区域中，简短和长期自我管理食物频率问卷在对日本中年和老年人饮食摄入量进行排名方面的有效性。
J Epidemiol. 2016 Aug 5;26(8):420-32. doi: 10.2188/jea.JE20150064. Epub 2016 Apr 9.
6
Associations between late and moderately preterm birth and smoking, alcohol, drug use and diet: a population-based case-cohort study.晚产和中度早产与吸烟、饮酒、吸毒和饮食的关联：基于人群的病例-对照研究。
Arch Dis Child Fetal Neonatal Ed. 2015 Nov;100(6):F486-91. doi: 10.1136/archdischild-2014-307265. Epub 2015 May 13.
7
Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study.低至中度孕期饮酒与特定出生结局风险：一项前瞻性队列研究。
Ann Epidemiol. 2015 Jan;25(1):46-54.e3. doi: 10.1016/j.annepidem.2014.10.011. Epub 2014 Oct 16.
8
Rationale and study design of the Japan environment and children's study (JECS).日本环境与儿童研究（JECS）的基本原理和研究设计。
BMC Public Health. 2014 Jan 10;14:25. doi: 10.1186/1471-2458-14-25.
9
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.靶向醛脱氢酶 2：新的治疗机会。
Physiol Rev. 2014 Jan;94(1):1-34. doi: 10.1152/physrev.00017.2013.
10
Association between maternal alcohol consumption in early pregnancy and pregnancy outcomes.母亲孕早期饮酒与妊娠结局的关系。
Obstet Gynecol. 2013 Oct;122(4):830-837. doi: 10.1097/AOG.0b013e3182a6b226.