特发性和发作性睡病患者 REM 睡眠行为障碍的生物标志物。
Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients.
机构信息
Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
出版信息
Ann Clin Transl Neurol. 2019 Sep;6(9):1872-1876. doi: 10.1002/acn3.50833. Epub 2019 Aug 6.
Abstract
To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.
摘要
为了寻找有区别的生物标志物，将 30 名特发性快速眼动睡眠行为障碍（iRBD）患者与 17 名 1 型发作性睡病相关的 RBD 患者进行比较。两组均接受了广泛的检查，包括皮肤活检以寻找磷酸化 α-突触核蛋白沉积物和整夜视频多导睡眠图。皮肤活检显示，86.7%的 iRBD 患者和无 1 型发作性睡病患者的磷酸化 α-突触核蛋白沉积物呈阳性。对视频多导睡眠图运动事件的分析显示，两组患者夜间的发生情况存在差异。iRBD 和由发作性睡病引起的 RBD 确实有不同的临床和病理发现，这证实了不同的病理生理学机制。
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