母系遗传：长寿程序通过卵黄滋养后代。

Maternal Inheritance: Longevity Programs Nourish Progeny via Yolk.

机构信息

Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

出版信息

Curr Biol. 2019 Aug 5;29(15):R748-R751. doi: 10.1016/j.cub.2019.06.050.

DOI:10.1016/j.cub.2019.06.050

PMID:31386852

Abstract

Epigenetic effects can be mediated by changes in chromatin state that are transmitted from parent to child via gametes, but support is gathering for maternal yolk, which is deposited into ooctyes, as an extranuclear epigenetic factor that can contribute to phenotypic plasticity across generations in Caenorhabditis elegans.

摘要

表观遗传效应可以通过染色质状态的变化来介导，这些变化通过配子从亲代传递到子代，但越来越多的证据表明，母源性卵黄作为一种核外表观遗传因子，可以在秀丽隐杆线虫中为跨代的表型可塑性做出贡献。