Department of Obstetrics and Gynecology, General Hospital of Daqing Oilfield, Daqing, Heilongjiang 163000, China.
Department of Obstetrics, Xi'an Gaoxin Hospital, Xi'an, Shaanxi 710075, China.
Biomed Pharmacother. 2019 Oct;118:109212. doi: 10.1016/j.biopha.2019.109212. Epub 2019 Aug 3.
Focally amplified lncRNA on chromosome 1 (FALEC) is novel lncRNA located in a focal amplicon on chromosome 1q21.2, and has been identified as an oncogenic properties in a variety of human cancers. However, there was no report about the expression pattern and biological function of FALEC in endometrial cancer. In our research, FALEC expression was increased in endometrial cancer tissue samples and cell lines compared with corresponding paracancerous normal tissue samples and cell line, respectively. Furthermore, we investigated the clinical significance of FALEC in endometrial cancer patients, and found endometrial cancer patients with advanced clinical stage or large tumor size had higher levels of FALEC expression than those with early clinical stage or small tumor size. The in vitro studies showed silencing of FALEC expression inhibited cell proliferation and arrested cell cycle at G0/G1. In conclusion, FALEC is overexpressed in endometrial cancer tissues and cells, and involved in regulating cell proliferation and cell-cycle.
1 号染色体上的局灶性扩增长链非编码 RNA（FALEC）是一种位于 1q21.2 染色体上局灶性扩增区域的新型长链非编码 RNA，已被鉴定为多种人类癌症中的致癌基因。然而，目前尚无关于 FALEC 在子宫内膜癌中的表达模式和生物学功能的报道。在我们的研究中，与相应的癌旁正常组织样本和细胞系相比，FALEC 在子宫内膜癌组织样本和细胞系中的表达增加。此外，我们研究了 FALEC 在子宫内膜癌患者中的临床意义，发现临床分期较晚或肿瘤较大的子宫内膜癌患者的 FALEC 表达水平高于临床分期较早或肿瘤较小的患者。体外研究表明，沉默 FALEC 的表达可抑制细胞增殖并将细胞周期阻滞在 G0/G1 期。综上所述，FALEC 在子宫内膜癌组织和细胞中高表达，并参与调节细胞增殖和细胞周期。
