非编码 RNA 在食管癌表观遗传修饰中的作用。
Involvement of noncoding RNAs in epigenetic modifications of esophageal cancer.
机构信息
Department of Pharmacy, Xiangya Hospital of Xiangya School of Medicine, Central South University, Changsha, PR China.
Department of the 2nd Thoracic Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, PR China; Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, PR China.
出版信息
Biomed Pharmacother. 2019 Sep;117:109192. doi: 10.1016/j.biopha.2019.109192. Epub 2019 Jul 11.
Esophageal cancer (EC) is a serious digestive malignancy and is a leading cause of cancer-related mortality. Apart from genetic mutations, many epigenetic alterations including DNA methylation and histone modifications associated with chromatin remodeling have been identified in the regulation of gene expression in EC. Recently, noncoding RNAs, and mainly lncRNAs and miRNAs, have been revealed to be involved in the epigenetic regulation of EC. In this review, we focus on describing new insights on epigenetic processes associated with noncoding RNAs, which have been characterized to be responsible for the development and progression of EC.
食管癌（EC）是一种严重的消化系统恶性肿瘤，是癌症相关死亡的主要原因。除了遗传突变外，在 EC 中基因表达的调控中还发现了许多与染色质重塑相关的表观遗传改变，包括 DNA 甲基化和组蛋白修饰。最近，非编码 RNA，主要是长链非编码 RNA 和 microRNA，已被证明参与 EC 的表观遗传调控。在这篇综述中，我们重点描述了与非编码 RNA 相关的表观遗传过程的新见解，这些过程被认为是 EC 发展和进展的原因。
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