骨桥蛋白表达在食管鳞癌中的预后价值：一项荟萃分析。
Prognostic value of osteopontin expression in esophageal squamous cell carcinoma: A meta-analysis.
机构信息
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
出版信息
Pathol Res Pract. 2019 Oct;215(10):152571. doi: 10.1016/j.prp.2019.152571. Epub 2019 Jul 30.
OBJECTIVE
To explore the prognostic role of osteopontin (OPN) overexpression in esophageal squamous cell carcinoma (ESCC).
METHODS
The PubMed, EMBASE, The Cochrane Library, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Data (CBM) and VIP databases were searched from the establishment dates of the databases to March 31, 2019, for potentially related studies. Stata 12.0 software was used for statistical analyses, and the hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to assess the correlation of OPN overexpression with the overall survival (OS) and progression-free survival (PFS) of ESCC patients.
RESULTS
A total of 8 studies involving 811 patients from China or Japan were included. OPN overexpression was demonstrated to be significantly associated with poor OS (HR = 1.86, 95% CI: 1.22-2.83, P = 0.004), with high heterogeneity (I = 61.2%, P = 0.012), and poor PFS (HR=1.63, 95% CI: 1.08-2.47, P = 0.020), without heterogeneity (I = 0.0%, P = 0.839). Subgroup analysis results were similar to the pooled results.
CONCLUSION
OPN overexpression might serve as a promising independent prognostic risk factor in Chinese and Japanese ESCC patients. However, more well-designed studies enrolling more patients are still needed to verify our findings.
目的
探讨骨桥蛋白（OPN）过表达在食管鳞癌（ESCC）中的预后作用。
方法
从数据库建立日期到 2019 年 3 月 31 日，检索 PubMed、EMBASE、The Cochrane Library、中国知网、万方、中国生物医学文献数据库和维普数据库，以寻找可能相关的研究。使用 Stata 12.0 软件进行统计分析，合并风险比（HRs）及其 95%置信区间（CIs），以评估 OPN 过表达与 ESCC 患者总生存期（OS）和无进展生存期（PFS）的相关性。
结果
共纳入来自中国或日本的 8 项研究，共计 811 例患者。结果显示，OPN 过表达与较差的 OS 显著相关（HR=1.86，95%CI：1.22-2.83，P=0.004），存在高度异质性（I²=61.2%，P=0.012），与较差的 PFS 也显著相关（HR=1.63，95%CI：1.08-2.47，P=0.020），无异质性（I²=0.0%，P=0.839）。亚组分析结果与汇总结果相似。
结论
OPN 过表达可能是中国和日本 ESCC 患者有前途的独立预后危险因素。然而，仍需要更多设计良好的、纳入更多患者的研究来验证我们的发现。
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