Shantou University Medical College, Shantou, 515041, Guangdong, People's Republic of China.
The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, 515041, Guangdong, People's Republic of China.
Amino Acids. 2023 Nov;55(11):1519-1529. doi: 10.1007/s00726-023-03343-9. Epub 2023 Oct 9.
Lysyl oxidase-like 4 (LOXL4), a member of lysyl oxidase family, is a copper and lysine tyrosylquinone-dependent amine oxidase that serves the role of catalyzing the cross-linking of elastin and collagen in the extracellular matrix. Numerous studies have shown a significant association between LOXL4 expression levels and tumor proliferation, migration, invasion and patients' prognosis and overall survival in different types of tumors. Here we review their relationship and the molecular pathogenesis behind them, aiming to explore the possibilities of LOXL4 as a prognostic marker for diverse carcinomas and provide some indications for further research in this field.
赖氨酰氧化酶样蛋白 4（LOXL4）是赖氨酰氧化酶家族的一员，是一种铜和赖氨酸酪氨酸醌依赖性胺氧化酶，其作用是催化细胞外基质中弹性蛋白和胶原蛋白的交联。大量研究表明，LOXL4 的表达水平与不同类型肿瘤中的肿瘤增殖、迁移、侵袭以及患者的预后和总生存率显著相关。本文综述了 LOXL4 与这些肿瘤的关系及其分子发病机制，旨在探讨 LOXL4 作为多种癌预后标志物的可能性，并为该领域的进一步研究提供一些依据。
