Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
National Heart Centre and Duke-National University of Singapore, Singapore, Singapore.
Clin Chem. 2019 Oct;65(10):1221-1227. doi: 10.1373/clinchem.2019.306621. Epub 2019 Aug 6.
The IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB) has directives and initiatives focused on providing evidence-based educational resources to aid and improve understanding around key analytical and clinical aspects of cardiac biomarkers used in clinical practice and the research setting. As a task force, we have previously published position statements and recommendations focused on use and analytical aspects of high-sensitivity cardiac troponin assays. The current educational document is the first from the C-CB highlighting important biochemical, analytical, and clinical aspects as they relate to the natriuretic peptides (NPs), including B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), with a focus on heart failure.
国际临床化学联合会心脏生物标志物临床应用委员会（C-CB）的工作重点是提供循证教育资源，以帮助和提高对临床实践和研究环境中使用的心脏生物标志物的关键分析和临床方面的理解。作为一个工作组，我们之前已经发布了侧重于高敏心肌肌钙蛋白检测分析和使用方面的立场声明和建议。当前的教育文件是 C-CB 发布的第一份文件，重点介绍了与利钠肽（NPs）相关的重要生化、分析和临床方面，包括 B 型利钠肽（BNP）和 N 末端 B 型利钠肽前体（NT-proBNP），重点关注心力衰竭。
