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镰状细胞贫血中淋巴细胞亚群的变化是由于脾功能丧失所致吗?

Are the changes of lymphocyte subsets in sickle cell anemia due to the loss of splenic function?

作者信息

Donadi E A, Falcão R P

机构信息

Department of Clinical Medicine, School of Medicine, Ribeirão Preto, Brazil.

出版信息

Acta Haematol. 1988;80(2):91-4. doi: 10.1159/000205610.

DOI:10.1159/000205610
PMID:3138877
Abstract

Lymphocyte subsets and K cell activity were evaluated in sickle cell anemia (SCA) and in splenectomized patients. Results showed that the number of total lymphocytes, T lymphocyte subsets and B lymphocytes were increased in SCA. However, individuals who had undergone splenectomy did not exhibit all these abnormalities, suggesting that the lack of the spleen apparently was not the unique factor responsible for the lymphocyte abnormalities seen in SCA patients.

摘要

对镰状细胞贫血(SCA)患者和脾切除患者的淋巴细胞亚群及K细胞活性进行了评估。结果显示,SCA患者的总淋巴细胞、T淋巴细胞亚群和B淋巴细胞数量均增加。然而,接受脾切除术的患者并未出现所有这些异常情况,这表明脾脏缺失显然不是导致SCA患者淋巴细胞异常的唯一因素。

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