Westermann J, Pabst R
Clin Exp Immunol. 1986 Apr;64(1):188-94.
Abnormal ratios of T helper-type to T suppressor-type lymphocytes in the blood of patients with replanted autologous splenic tissue led to the present study in rats. Lymphocyte subsets were studied in the blood, mesenteric lymph nodes and spleen after autotransplantation and compared to splenectomized and control rats. In the blood of transplanted rats the percentage of T and T helper-type lymphocytes was lower, in the spleen B lymphocytes higher and T lymphocytes and their subsets lower. Comparable changes were seen in the lymph nodes. The data of the mesenteric lymph nodes in autotransplanted rats did not differ from splenectomized animals. Even after 37 weeks the regenerated splenic tissue only reached 13% of the weight of control rats and the absolute lymphocyte number was only 2.5% of a normal spleen. Splenic autotransplantation results in a small hypocellular mass of splenic tissue with a different composition of lymphocyte subsets and does not correct the obvious effect of splenectomy on lymphocyte subpopulations in lymph nodes.
自体脾组织移植患者血液中辅助性T淋巴细胞与抑制性T淋巴细胞的比例异常，引发了本项对大鼠的研究。对自体移植后血液、肠系膜淋巴结和脾脏中的淋巴细胞亚群进行了研究，并与脾切除大鼠和对照大鼠进行了比较。在移植大鼠的血液中，T淋巴细胞和辅助性T淋巴细胞的百分比降低，脾脏中B淋巴细胞百分比升高，T淋巴细胞及其亚群百分比降低。在淋巴结中也观察到了类似的变化。自体移植大鼠肠系膜淋巴结的数据与脾切除动物的数据没有差异。即使在37周后，再生的脾组织重量仅达到对照大鼠的13%，绝对淋巴细胞数量仅为正常脾脏的2.5%。脾自体移植导致脾组织细胞数量少且淋巴细胞亚群组成不同，并且不能纠正脾切除术对淋巴结中淋巴细胞亚群的明显影响。
