Wang W C, George S L, Wilimas J A
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tenn.
Acta Haematol. 1988;80(2):99-102. doi: 10.1159/000205612.
Transcutaneous electrical nerve stimulation (TENS) has been used in a variety of acute and chronic painful conditions, but has not been studied in sickle cell pain crises. We compared TENS versus placebo in a randomized, double-blind, cross-over study involving 60 trials in 4 crisis severity categories. TENS electrodes were applied to the area of severest pain and patients' pain ratings and medication usage were evaluated over a 4-hour period. Pain ratings and analgesic requirements at 1 and 4 h from onset of study were similar in the TENS and placebo groups. Patients assessments of overall treatment efficacy indicated that TENS was more frequently helpful, but there was a substantial placebo effect. Although the value of TENS in this condition was not established in this study, further trials, using varied stimulation parameters, are warranted.
经皮电刺激神经疗法（TENS）已被用于多种急慢性疼痛病症，但尚未在镰状细胞疼痛危象中进行研究。我们在一项随机、双盲、交叉研究中比较了TENS与安慰剂，该研究涉及4种危机严重程度类别中的60次试验。将TENS电极置于最疼痛区域，并在4小时内评估患者的疼痛评分和药物使用情况。TENS组和安慰剂组在研究开始后1小时和4小时的疼痛评分及镇痛需求相似。患者对总体治疗效果的评估表明，TENS更常有效，但存在显著的安慰剂效应。尽管本研究未确定TENS在这种病症中的价值，但有必要使用不同的刺激参数进行进一步试验。
