Department of Psychiatry and Mental Health and Neuroscience Institute, Brain Behaviour Unit, Groote Schuur Hospital, University of Cape Town, OPD H-Floor, Observatory, Cape Town, 7925, South Africa.
SU/UCT MRC Unit on Risk and Resilience in Mental Disorders and Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
J Neuroimmune Pharmacol. 2019 Dec;14(4):679-687. doi: 10.1007/s11481-019-09870-1. Epub 2019 Aug 6.
Dysregulated expression of neuro-immune markers has previously been linked to HIV-associated neurocognitive impairment. We undertook an exploratory approach in a HIV clade-C cohort, investigating the association between eight immune markers and neurocognitive performance in 99 HIV+ and 51 HIV- participants. Markers were selected on preliminary and putative evidence of their link to key neuro-immune functions. Cognitive performance was established using a battery of tests sensitive to HIV-associated neurocognitive impairment, with domain-based scores utilized in analysis. The markers Thymidine phosphorylase (TYMP) and Neutrophil gelatinase-associated lipocalin (NGAL) were significantly higher while Matrix Metalloproteinase (MMP)9 was significantly lower in HIV+ participants. Our results further showed that in the HIV+ group, worse psychomotor processing speed was associated with higher TYMP and NGAL levels and worse motor function was associated with higher NGAL levels. Future studies should explore the underlying mechanisms of these markers in HIV-associated neurocognitive impairment. Graphical Abstract The association of peripheral immune markers with neurocognitive performance in South African HIV-positive patients.
神经免疫标志物的失调表达先前与 HIV 相关的神经认知障碍有关。我们在 HIV 克娄巴雷组中采用了一种探索性方法，研究了 99 名 HIV 阳性和 51 名 HIV 阴性参与者中 8 种免疫标志物与神经认知表现之间的关联。标志物是根据其与关键神经免疫功能的联系的初步和假定证据选择的。认知表现是使用一系列对 HIV 相关神经认知障碍敏感的测试来确定的，分析中使用了基于域的分数。在 HIV 阳性参与者中，胸苷磷酸化酶（TYMP）和中性粒细胞明胶酶相关脂质运载蛋白（NGAL）显着升高，而基质金属蛋白酶（MMP）9 显着降低。我们的结果还表明，在 HIV 阳性组中，较差的精神运动处理速度与 TYMP 和 NGAL 水平升高相关，而较差的运动功能与 NGAL 水平升高相关。未来的研究应探讨这些标志物在 HIV 相关神经认知障碍中的潜在机制。
