Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Division of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, South Korea.
J Periodontol. 2020 Mar;91(3):369-376. doi: 10.1002/JPER.19-0068. Epub 2019 Aug 26.
To examine whether periodontitis is associated with the presence and severity of radiographic knee osteoarthritis (OA).
Using data from the Korea National Health and Nutrition Examination Survey between 2010 and 2013, participants over the age of 50 were included in this study. Dental examinations and knee radiographs are performed in participants aged ≥50 years in this cohort. Periodontitis was defined using the community periodontal index, which was determined by measuring periodontal probing depth. The definition of radiographic knee OA was based on the Kellgren-Lawrence (K-L) grading system, which determined a K-L class ≥2 to be radiographic knee OA. The associations between periodontitis and presence and severity of radiographic knee OA were examined using logistic regression analyses.
Among 7969 total participants, 965 men and 2078 women had radiographic knee OA. Periodontitis was observed in 1,185 (39.4%) people among those who had radiographic knee OA. Periodontitis (adjusted odds radio [aOR] 1.21, 95% confidence interval 1.05 to 1.40) was associated with radiographic knee OA after adjusting for variables including age, sex, body mass index, socioeconomic status, diabetes, and dental status. Participants were more likely to have radiographic knee OA as the severity of periodontitis increased (non-severe periodontitis, aOR 1.14 [0.98 to 1.32]; severe periodontitis, aOR 1.47 [1.17 to 1.85]). Moreover, the presence of periodontitis significantly increased with an increasing K-L class (class 1, aOR 1.30 [1.09 to 1.54]; class 2, aOR 1.32 [1.08 to 1.60]; class 3, aOR 1.39 [1.14 to 1.70]; class 4, aOR 1.45 [1.11 to 1.90]).
Periodontitis is associated with the presence and severity of radiographic knee OA.
探讨牙周炎与放射学膝关节骨关节炎（OA）的存在和严重程度的关系。
本研究使用了 2010 年至 2013 年韩国国家健康和营养检查调查的数据，纳入了年龄在 50 岁以上的参与者。在该队列中，年龄在 50 岁及以上的参与者接受了牙科检查和膝关节 X 光检查。牙周炎使用社区牙周指数（community periodontal index）来定义，该指数通过测量牙周探诊深度来确定。放射学膝关节 OA 的定义基于 Kellgren-Lawrence（K-L）分级系统，将 K-L 分级≥2 定义为放射学膝关节 OA。使用逻辑回归分析来检验牙周炎与放射学膝关节 OA 的存在和严重程度之间的关系。
在 7969 名总参与者中，有 965 名男性和 2078 名女性患有放射学膝关节 OA。在患有放射学膝关节 OA 的人群中，有 1185 人（39.4%）患有牙周炎。调整年龄、性别、体重指数、社会经济地位、糖尿病和牙齿状况等变量后，牙周炎（调整后的优势比[aOR]1.21，95%置信区间 1.05 至 1.40）与放射学膝关节 OA 相关。随着牙周炎严重程度的增加，参与者患有放射学膝关节 OA 的可能性也增加（非严重牙周炎，aOR 1.14[0.98 至 1.32]；严重牙周炎，aOR 1.47[1.17 至 1.85]）。此外，牙周炎的存在随着 K-L 分级的增加而显著增加（K-L 分级 1，aOR 1.30[1.09 至 1.54]；K-L 分级 2，aOR 1.32[1.08 至 1.60]；K-L 分级 3，aOR 1.39[1.14 至 1.70]；K-L 分级 4，aOR 1.45[1.11 至 1.90]）。
牙周炎与放射学膝关节 OA 的存在和严重程度有关。
