Department of Medicine, College of Medicine, Inha University, Incheon, Korea.
Department of Orthopaedic Surgery, College of Medicine, Inha University, Incheon, Korea.
Yonsei Med J. 2024 Sep;65(9):519-526. doi: 10.3349/ymj.2023.0456.
This study aimed to investigate the correlation between serum creatinine levels and the presence and severity of radiographic knee osteoarthritis (OA) in individuals aged ≥50 years while adjusting for potential confounders.
Cross-sectional data from the 2009-2011 Korea National Health and Nutrition Examination Survey comprising 3428 individuals aged ≥50 years were utilized. The Kellgren-Lawrence (K-L) grading scale was used to assess the radiographic presence and severity of knee OA. Logistic regression and receiver operating characteristic analyses were used to investigate the association between serum creatinine levels and the presence of knee OA, whereas ordinal regression was used to assess the impact of creatinine levels on knee OA severity.
The presence of radiographic knee OA conferred by low serum creatinine levels was found to be significant in both sexes [odds ratio (OR), 0.118; 95% confidence interval (CI), 0.045-0.314, <0.001 for men; OR, 0.148; 95% CI, 0.040-0.549, =0.004 for women]. Low serum creatinine was significantly associated with knee OA-graded K-L severity in each sex-based group [β, -1.923; standard error, 0.478; <0.001 for men and β, -1.532; SE, 0.575; =0.008 for women].
Low serum creatinine level was associated with a higher presence of knee OA in both men and women, and was also linked to the severity of the disease. These findings suggest that the serum creatinine level may be a potential biomarker for assessing the presence and severity of knee OA.
本研究旨在探讨血清肌酐水平与≥50 岁人群膝关节骨关节炎（OA）的存在和严重程度之间的相关性，同时调整潜在的混杂因素。
利用 2009-2011 年韩国国家健康和营养调查的横断面数据，纳入 3428 名≥50 岁的个体。采用 Kellgren-Lawrence（K-L）分级量表评估膝关节 OA 的放射学存在和严重程度。使用逻辑回归和受试者工作特征分析来研究血清肌酐水平与膝关节 OA 之间的关联，而使用有序回归来评估肌酐水平对膝关节 OA 严重程度的影响。
在男性和女性中，低血清肌酐水平与放射学膝关节 OA 的存在均具有显著相关性（比值比[OR]，0.118；95%置信区间[CI]，0.045-0.314，<0.001；OR，0.148；95%CI，0.040-0.549，=0.004）。低血清肌酐与每个性别组的膝关节 OA-K-L 严重程度分级显著相关[男性的β值为-1.923，标准误为 0.478，<0.001；女性的β值为-1.532，标准误为 0.575，=0.008]。
低血清肌酐水平与男性和女性膝关节 OA 的存在呈正相关，且与疾病的严重程度相关。这些发现表明，血清肌酐水平可能是评估膝关节 OA 存在和严重程度的潜在生物标志物。
