Pineault M, Chessex P, Bisaillon S, Lepage D, Dallaire L
Perinatal Service, Hospital Ste-Justine, Montreal, Quebec, Canada.
Am J Clin Nutr. 1988 Oct;48(4):1065-9. doi: 10.1093/ajcn/48.4.1065.
As part of an ongoing study on the influence of intravenous glucose and fat on nitrogen metabolism we evaluated the relationship between the source of infused energy and plasma amino acid levels. Thirty-two studies were performed in 16 appropriate-for-gestational-age newborn infants (birth weight, 2150 +/- 115 g; means +/- SEM). In a crossover design each patient received two 6-d periods of isocaloric and isonitrogenous infusions, differing only by the source of calories (high or low fat intakes). For an energy intake of 80 kcal.kg-1.d-1 (335 kJ.kg-1.d-1) there was a significant hypoaminoacidemia (2338 +/- 185 vs 2937 +/- 196 mumol/L, high fat vs low fat) under the high-glucose intake. These data suggest that above an energy intake of 60 kcal.kg-1.d-1 (251 kJ.kg-1.d-1) there is a threshold at which changes in plasma amino acid levels are triggered by variations in the source of infused energy. Careful examination of all variables, including energy sources, is essential when aminograms are compared.
作为一项关于静脉输注葡萄糖和脂肪对氮代谢影响的正在进行的研究的一部分，我们评估了输注能量的来源与血浆氨基酸水平之间的关系。对16名适于胎龄的新生儿（出生体重2150±115g；均值±标准误）进行了32项研究。采用交叉设计，每名患者接受两个为期6天的等热量、等氮量输注期，两者仅热量来源不同（高脂肪或低脂肪摄入）。对于80kcal·kg⁻¹·d⁻¹（335kJ·kg⁻¹·d⁻¹）的能量摄入，在高葡萄糖摄入情况下存在显著的低氨基酸血症（高脂肪摄入时为2338±185μmol/L，低脂肪摄入时为2937±196μmol/L）。这些数据表明，当能量摄入超过60kcal·kg⁻¹·d⁻¹（251kJ·kg⁻¹·d⁻¹）时，存在一个阈值，在该阈值下输注能量来源的变化会引发血浆氨基酸水平的改变。在比较氨基酸谱时，仔细检查所有变量，包括能量来源，至关重要。
