Servicio de Reumatología, Hospital Clínico Virgen de la Victoria, Málaga, Spain.
Servicio de Endocrinología, Hospital Universitario Quironsalud, Madrid, Spain.
Gynecol Endocrinol. 2020 Feb;36(2):93-95. doi: 10.1080/09513590.2019.1650346. Epub 2019 Aug 7.
To evaluate numerous publications that question the bone and extraosseous benefits of vitamin D diet supplementation based on results, which often transcend to public opinion, but are not well interpreted. This may have negative consequences on compliance of patients under vitamin D supplementation. Critical appraisal of several articles on vitamin D supplementation and its relationship with fractures, falls, cardiovascular diseases, and cancer incidence. Such publications have certain limitations (i.e. patients excluded because of a diagnosis of osteoporosis, or at a higher risk for fractures and falls, or because they have a vitamin D deficiency, etc.), and conclusions and/or subsequent recommendations should be approached with caution. Our research shows that patients with osteoporosis, vitamin D deficiency, and at high risk of fractures and falls should not discontinue vitamin D supplementation (often associated with calcium). It is becoming increasingly evident that patients with hypovitaminosis D are those that gain a maximal benefit from vitamin D supplementation.
评估了大量质疑维生素 D 饮食补充对骨骼和骨外益处的出版物，这些结果常常超越了公众意见，但并未得到很好的解释。这可能对接受维生素 D 补充的患者的依从性产生负面影响。对几项关于维生素 D 补充及其与骨折、跌倒、心血管疾病和癌症发病率关系的文章进行了批判性评估。这些出版物存在一定的局限性（例如，由于骨质疏松症诊断、骨折和跌倒风险较高、或维生素 D 缺乏等原因而排除的患者），因此应谨慎对待结论和/或随后的建议。我们的研究表明，患有骨质疏松症、维生素 D 缺乏症和骨折及跌倒高风险的患者不应停止维生素 D 补充（通常与钙一起补充）。越来越明显的是，维生素 D 缺乏症患者从维生素 D 补充中获益最大。
