Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania.
J Biol Rhythms. 2019 Dec;34(6):584-595. doi: 10.1177/0748730419868136. Epub 2019 Aug 7.
Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcription. Although much of the focus with respect to clock mechanisms has been on the regulation of transcription and on the stability and activity of clock proteins, it is clear that other regulatory processes also have to be involved to explain aspects of clock function. Here, we review the role of alternative splicing in circadian clocks. Starting with a discussion of the clock and then extending to other major circadian model systems, we describe how the control of alternative splicing enables organisms to maintain their circadian clocks as well as to respond to environmental inputs, in particular to temperature changes.
生物钟驱动着多种生物体的生理和行为的日常节律，并使这些节律与光照和温度的环境周期同步。生物钟的基本机制由一个转录-翻译反馈回路组成，其中关键的生物钟蛋白负调控它们自身的转录。尽管时钟机制的大部分焦点一直集中在转录的调控以及生物钟蛋白的稳定性和活性上，但很明显，为了解释生物钟功能的某些方面，还必须涉及其他调控过程。在这里，我们回顾了选择性剪接在生物钟中的作用。我们从生物钟开始讨论，然后扩展到其他主要的生物钟模型系统，描述了选择性剪接的控制如何使生物体既能维持生物钟，又能对环境输入（特别是温度变化）做出反应。
