Zhu Yannan, Jin Hongxing, Huang You
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Chem Commun (Camb). 2019 Sep 4;55(68):10135-10137. doi: 10.1039/c9cc05276c. Epub 2019 Aug 7.
An unprecedented [3+3]-annulation of p-quinamines and nitrile imines was developed, affording a series of 1,2,4-triazinone derivatives in moderate to excellent yields with excellent diastereoselectivity. This cycloaddition expands the scope of p-quinamines to the construction of six-membered nitrogen-containing heterocyclic compounds.
开发了一种前所未有的对醌胺与腈亚胺的[3+3]环化反应，以中等至优异的产率和出色的非对映选择性得到了一系列1,2,4-三嗪酮衍生物。这种环加成反应扩展了对醌胺在构建含氮六元杂环化合物方面的应用范围。
