From the Departments of Pathology (Drs Al Hmada, Bernieh, Lewin, and Allen), and Radiology (Dr Morris), University of Mississippi Medical Center, Jackson.
Arch Pathol Lab Med. 2020 Jan;144(1):15-17. doi: 10.5858/arpa.2019-0191-RA. Epub 2019 Aug 7.
CONTEXT.—: Chondroblastoma-like osteosarcoma is an exceedingly rare variant of osteosarcoma, with 22 cases reported in the English-language literature. The tumor is slightly more common in males, with a broad age range (from childhood to elderly). The most commonly involved bones are the metatarsus and tibia, followed by the femur. Most tumors have malignant or worrisome radiographic findings. Prognosis is variable, depending on the presence or absence of lung metastases, local recurrence, and probably tumor location. Histologically, chondroblastoma-like osteosarcoma is characterized by monotonous, minimally to moderately atypical rounded cells with ovoid nuclei resembling chondroblastoma, and abnormal osteoid deposition with destruction of the bone.
OBJECTIVE.—: To review the clinical, radiographic, and histopathologic features of chondroblastoma-like osteosarcoma.
DATA SOURCES.—: PubMed-published chondroblastoma-like osteosarcoma cases in the English-language literature.
CONCLUSIONS.—: Although exceedingly rare, chondroblastoma-like osteosarcoma should be considered in the differential diagnosis of chondroblastoma, especially in the presence of radiologic findings suggestive of an aggressive lesion.
软骨母细胞瘤样骨肉瘤是一种极其罕见的骨肉瘤变体，在英语文献中仅报道了 22 例。该肿瘤在男性中略多见，发病年龄范围广泛（从儿童到老年）。最常受累的骨骼是跖骨和胫骨，其次是股骨。大多数肿瘤具有恶性或令人担忧的影像学表现。预后因是否存在肺转移、局部复发以及可能的肿瘤位置而有所不同。组织学上，软骨母细胞瘤样骨肉瘤的特征为单调、轻度至中度非典型圆形细胞，具有类似于软骨母细胞瘤的卵圆形核，以及异常的骨样组织沉积和骨破坏。
回顾软骨母细胞瘤样骨肉瘤的临床、影像学和组织病理学特征。
PubMed 发表的英语文献中的软骨母细胞瘤样骨肉瘤病例。
尽管极其罕见，但在鉴别诊断软骨母细胞瘤时应考虑软骨母细胞瘤样骨肉瘤，特别是在存在提示侵袭性病变的影像学表现时。
