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定制超短柄3D打印假体在骨缺损重建中的应用:单中心分析

The application of custom 3D-printed prostheses with ultra-short stems in the reconstruction of bone defects: a single center analysis.

作者信息

Zhang Peng, Tian Wen, Li Po, Zhang Fan, Qu Guoxin, Du Xinhui, Liu Guancong, Niu Xiaoying

机构信息

Department of Orthopedic and Soft Tissue, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.

出版信息

Front Bioeng Biotechnol. 2024 Jan 25;12:1349819. doi: 10.3389/fbioe.2024.1349819. eCollection 2024.

Abstract

Considering the advantages and widespread presence of 3D-printing technology in surgical treatments, 3D-printed porous structure prostheses have been applied in a wide range of the treatments of bone tumor. In this research, we aimed to assess the application values of the 3D-printed custom prostheses with ultra-short stems for restoring bone defects and maintaining arthrosis in malignant bone tumors of lower extremities in children. Seven cases of pediatric patients were included in this study. In all cases, the prostheses were porous titanium alloy with ultra-short stems. MSTS 93 (Musculoskeletal Tumor Society) scores were recorded for the functional recovery of the limbs. VAS (Visual analogue scale) scores were utilized to assess the degree of painfulness for the patients. X-ray and MRI (magnetic resonance imaging) were applied to evaluate the bone integration, prostheses aseptic loosening, prostheses fracture, wound healing, and tumor recurrence during follow-up. During follow-up, none of the patients developed any postoperative complications, including prostheses aseptic loosening, prostheses fracture, or tumor recurrence. Radiological examinations during the follow-up showed that prostheses implanted into the residual bone were stably fitted and bone defects were effectively reconstructed. The MSTS 93 scores were 24.9 ± 2.9 (20-28). VAS scores were decreased to 5.8 ± 1.2 (4.0-7.0). No statistically significant differences in leg length discrepancy were observed at the time of the last follow-up. 3D-printing technology can be effectively applied throughout the entire surgical treatment procedures of malignant bone tumors, offering stable foundations for the initial stability of 3D-printed prostheses with ultra-short stems through preoperative design, intraoperative precision operation, and personalized prosthesis matching. With meticulous postoperative follow-up, close monitoring of postoperative complications was ensured. These favorable outcomes indicate that the utilization of 3D-printed custom prostheses with ultra-short stems is a viable alternative for reconstructing bone defects. However, further investigation is warranted to determine the long-term effectiveness of the 3D-printing technique.

摘要

考虑到3D打印技术在外科治疗中的优势及其广泛应用,3D打印多孔结构假体已被广泛应用于骨肿瘤的多种治疗中。在本研究中,我们旨在评估具有超短柄的3D打印定制假体在儿童下肢恶性骨肿瘤中修复骨缺损和维持关节功能的应用价值。本研究纳入了7例儿科患者。所有病例中,假体均为带超短柄的多孔钛合金。记录MSTS 93(肌肉骨骼肿瘤学会)评分以评估肢体功能恢复情况。采用视觉模拟评分法(VAS)评估患者的疼痛程度。在随访期间,应用X线和磁共振成像(MRI)评估骨整合情况、假体无菌性松动、假体骨折、伤口愈合及肿瘤复发情况。随访期间,所有患者均未出现任何术后并发症,包括假体无菌性松动、假体骨折或肿瘤复发。随访期间的影像学检查显示,植入残余骨的假体贴合稳定,骨缺损得到有效重建。MSTS 93评分为24.9±2.9(20 - 28)。VAS评分降至5.8±1.2(4.0 - 7.0)。末次随访时,双下肢长度差异无统计学意义。3D打印技术可有效应用于恶性骨肿瘤的整个手术治疗过程,通过术前设计、术中精准操作和个性化假体匹配,为带超短柄的3D打印假体的初始稳定性提供坚实基础。通过细致的术后随访,确保了对术后并发症的密切监测。这些良好结果表明,使用带超短柄的3D打印定制假体是重建骨缺损的一种可行选择。然而,有必要进一步研究以确定3D打印技术的长期有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675c/10850231/528f05fa5f9e/fbioe-12-1349819-g001.jpg

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