Berman Hannah S, Villa Natalie M, Shi Vivian Y, Hsiao Jennifer L
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Division of Dermatology, Department of Medicine, University of Arizona, Tucson, AZ, USA.
J Dermatolog Treat. 2021 Mar;32(2):261-263. doi: 10.1080/09546634.2019.1654067. Epub 2019 Aug 25.
Hidradenitis suppurativa (HS) is a debilitating skin condition whose pathogenesis is poorly understood, although interleukin (IL)-23 may play a role. IL-23 is also implicated in the pathogenesis of Crohn's disease (CD) and psoriasis, both of which can occur in patients with HS.
We present the case of a 28-year-old woman with HS, psoriasis, and CD, who was successfully treated with guselkumab after failing multiple other biologic agents.
Guselkumab represents a promising therapeutic option for recalcitrant HS patients with inflammatory comorbidities in which IL-23 plays a role.
化脓性汗腺炎（HS）是一种使人衰弱的皮肤疾病，其发病机制尚不清楚，不过白细胞介素（IL）-23可能起作用。IL-23也与克罗恩病（CD）和银屑病的发病机制有关，这两种疾病都可能发生在HS患者身上。
我们报告了一名28岁患有HS、银屑病和CD的女性病例，该患者在多种其他生物制剂治疗失败后，使用古塞库单抗成功治愈。
对于IL-23起作用的伴有炎症合并症的顽固性HS患者，古塞库单抗是一种有前景的治疗选择。
