Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK.
Chemistry. 2019 Oct 11;25(57):13114-13118. doi: 10.1002/chem.201903590. Epub 2019 Sep 13.
A photochemical approach to polysubstituted heterocycles using UV-induced alkene isomerization is described. The method allows for the synthesis of disubstituted furans and pyrroles under mild and neutral conditions and also provides access to a class of trisubstituted furans pertinent to natural-product synthesis. The method has broad functional-group tolerance and many richly decorated heterocycles have been prepared incorporating functional groups that are unstable under Brønsted and Lewis acidic conditions.
本文描述了一种光化学方法，通过 UV 诱导的烯烃异构化来合成多取代杂环化合物。该方法在温和、中性条件下能够合成二取代呋喃和吡咯，还可以得到一类与天然产物合成相关的三取代呋喃。该方法具有广泛的官能团容忍性，许多经过富装饰的杂环化合物已经被制备出来，其中包含了在布朗斯特和路易斯酸性条件下不稳定的官能团。
