You Changming, Zhang Zhenming, Tu Yongliang, Tang Hong, Wang Yuanfeng, Long Da, Zhao Junfeng
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, People's Republic of China.
School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, People's Republic of China.
J Org Chem. 2020 Mar 6;85(5):3902-3910. doi: 10.1021/acs.joc.9b03006. Epub 2020 Jan 24.
A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of β-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance.
描述了一种通过β-酮化合物与二氯乙烯的碱促进多米诺反应合成2,3-二取代和2,3,5-三取代呋喃的简便直接策略。这种无过渡金属的方法在操作简单的反应条件下进行，具有起始原料易得、底物范围广和良好的官能团耐受性等特点。
