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Progression of prostate carcinoma is promoted by adipose stromal cell-secreted CXCL12 signaling in prostate epithelium.前列腺上皮中脂肪基质细胞分泌的CXCL12信号传导促进前列腺癌的进展。
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Ablation of Stromal Cells with a Targeted Proapoptotic Peptide Suppresses Cancer Chemotherapy Resistance and Metastasis.用靶向促凋亡肽消融基质细胞可抑制癌症化疗耐药性和转移。
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本文引用的文献

1
Coping with chemoresistance in prostate cancer-co-targeting of adipose stromal cells?应对前列腺癌中的化疗耐药性——脂肪基质细胞的共同靶向作用？
Transl Androl Urol. 2019 Jul;8(Suppl 3):S250-S253. doi: 10.21037/tau.2019.01.03.
2
Adipose tissue: enabler of prostate cancer aggressive behavior.脂肪组织：前列腺癌侵袭性行为的促成因素。
Transl Androl Urol. 2019 Jul;8(Suppl 3):S242-S245. doi: 10.21037/tau.2019.01.07.
3
Targeting the adipose tissue to fight prostate cancer.靶向脂肪组织对抗前列腺癌。
Transl Androl Urol. 2019 Jul;8(Suppl 3):S229-S231. doi: 10.21037/tau.2019.01.13.
4
Taking aim at a challenging target in pre-clinical models of prostate cancer.瞄准前列腺癌临床前模型中的一个具有挑战性的靶点。
Transl Androl Urol. 2019 Mar;8(Suppl 1):S88-S90. doi: 10.21037/tau.2019.01.02.
5
Adipose stromal cell targeting suppresses prostate cancer epithelial-mesenchymal transition and chemoresistance.靶向脂肪基质细胞可抑制前列腺癌上皮间质转化和化疗耐药性。
Oncogene. 2019 Mar;38(11):1979-1988. doi: 10.1038/s41388-018-0558-8. Epub 2018 Oct 25.
6
Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors.癌症与脂肪：脂肪组织与肿瘤之间的相互作用
Trends Cancer. 2018 May;4(5):374-384. doi: 10.1016/j.trecan.2018.03.004. Epub 2018 Apr 5.
7
Proinflammatory CXCL12-CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice.促炎CXCL12-CXCR4/CXCR7信号轴驱动肥胖小鼠中Myc诱导的前列腺癌。
Cancer Res. 2017 Sep 15;77(18):5158-5168. doi: 10.1158/0008-5472.CAN-17-0284. Epub 2017 Jul 7.
8
CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment.CXCL1 介导肥胖相关脂肪基质细胞在肿瘤微环境中的迁移和功能。
Nat Commun. 2016 May 31;7:11674. doi: 10.1038/ncomms11674.
9
Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.前列腺周围脂肪细胞是肥胖状态下前列腺癌进展的驱动因素。
Nat Commun. 2016 Jan 12;7:10230. doi: 10.1038/ncomms10230.
10
Targeted Proapoptotic Peptides Depleting Adipose Stromal Cells Inhibit Tumor Growth.靶向促凋亡肽消耗脂肪基质细胞可抑制肿瘤生长。
Mol Ther. 2016 Feb;24(1):34-40. doi: 10.1038/mt.2015.155. Epub 2015 Aug 28.

The role of adipose stroma in prostate cancer aggressiveness.

作者信息

Kolonin Mikhail G, DiGiovanni John

机构信息

The Brown Foundation Institute of Molecular Medicine for the Prevention of Disease, The University of Texas Health Sciences Center at Houston, Houston, TX, USA.

Division of Pharmacology and Toxicology, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX, USA.

出版信息

Transl Androl Urol. 2019 Jul;8(Suppl 3):S348-S350. doi: 10.21037/tau.2019.04.07.

DOI:10.21037/tau.2019.04.07
PMID:31392166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6642957/
Abstract
摘要