Biosciences, Council for Scientific and Industrial Research, Pretoria, South Africa.
Defence, Peace, Safety and Security, Council for Scientific and Industrial Research, Pretoria, South Africa.
Nat Prod Res. 2021 Jun;35(12):1968-1976. doi: 10.1080/14786419.2019.1648457. Epub 2019 Aug 8.
A novel cycloartanol () and an acylated Sutherlandioside D () together with two known cycloartane derivatives, Sutherlandioside B () and Sutherlandioside A (), were isolated from the aerial parts of . The structures of these compounds were established by a combination of 1- and 2-D NMR techniques and further confirmed by high resolution ToF mass spectrometry (HRToFMS). Preliminary biological studies were also conducted to assess the activity of different plant extracts, fractions and compounds on cytokine expression. Compounds and prompted an increase in IL-6 expression while compound showed a reduced IL-6 expression compared to the controls. Compound is an effective suppressor of IL-10 expression. The plant compounds inhibited the expression of the two cytokines, IL-10 and TNFα. The results of the assays suggested that some components in the plant extract influence the immune system by suppressing the expression of IL-6, IL-10 and TNFα.
从 Sutherlandia frutescens 的地上部分分离得到了一种新型环阿尔廷醇（）和一种酰化的 Sutherlandioside D（），以及两种已知的环阿尔廷烷衍生物，Sutherlandioside B（）和 Sutherlandioside A（）。这些化合物的结构通过 1D 和 2D NMR 技术的组合确定，并通过高分辨率飞行时间质谱（HRToFMS）进一步证实。还进行了初步的生物研究，以评估不同植物提取物、馏分和化合物对细胞因子表达的活性。化合物和促使 IL-6 表达增加，而化合物与对照组相比，IL-6 表达降低。化合物是 IL-10 表达的有效抑制剂。植物化合物抑制了两种细胞因子 IL-10 和 TNFα 的表达。这些测定结果表明，植物提取物中的一些成分通过抑制 IL-6、IL-10 和 TNFα 的表达来影响免疫系统。
