Metel'skaya V A, Ceska R, Perova N V, Sobra J
Institute of Preventive Cardiology, Academy of Medical Sciences of the USSR, Moscow.
Cor Vasa. 1988;30(3):168-76.
The level of blood plasma apolipoproteins A-I and B was studied in Moscow and Prague residents with different types of hyperlipoproteinaemia (HLP). The analysis proceeded in two directions. On the one hand, lipoprotein (LP) spectra in residents of both cities with the same type of LP disturbance (HLP type IIa, IIb or IV) were compared; in Prague lipid and apolipoprotein content was compared in inhabitants with a normal lipid level and those with HLP types I, III and V. The analysis showed that inhabitants of Prague with types II and IV HLP have a higher concentrations of high density LP cholesterol. At the same time, it was found that the apolipoprotein profile of blood plasma LP in HLP patients was similar to that in patients living elsewhere. The authors regard comparative study of LP system disturbances in residents of different cities and countries differing in their geographical, ethnic and ecological conditions as a promising approach to understanding the mechanisms responsible for the development of HLP.
对莫斯科和布拉格患有不同类型高脂蛋白血症（HLP）的居民的血浆载脂蛋白A-I和B水平进行了研究。分析从两个方向进行。一方面，比较了两个城市中患有相同类型脂蛋白紊乱（IIa型、IIb型或IV型HLP）的居民的脂蛋白（LP）谱；在布拉格，比较了血脂水平正常的居民与患有I型、III型和V型HLP的居民的脂质和载脂蛋白含量。分析表明，患有II型和IV型HLP的布拉格居民的高密度LP胆固醇浓度较高。同时，发现HLP患者血浆LP的载脂蛋白谱与其他地方的患者相似。作者认为，对地理、种族和生态条件不同的不同城市和国家居民的LP系统紊乱进行比较研究，是理解HLP发病机制的一种有前景的方法。
