精浆代谢产物介导多种环境污染物与中国男性精液质量的关联。
Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men.
机构信息
Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.
Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.
出版信息
Environ Int. 2019 Nov;132:105066. doi: 10.1016/j.envint.2019.105066. Epub 2019 Aug 6.
Environmental exposure to arsenic, phthalate esters (PAEs) and perfluorinated compounds (PFCs) has been associated with human semen quality. However, the epidemiological "black-box" of these associations remains poorly uncovered. In this study, based on the association analysis between arsenic, PAE and PFC exposure and semen quality parameters (i.e., semen volume, sperm concentration, sperm count, progressive motility, total motility and normal morphology) in a Chinese male population, we explored the seminal plasma metabolic signatures that may mediate the exposure-outcome relations by using the meet-in-metabolite-analysis (MIMA) approach. As a result, a negative association was found between DMA and sperm concentration, whereas MEHP and PFHxS were positively associated with sperm count and concentration, respectively. Metabolomics analysis revealed that sixteen and twenty-two seminal plasma metabolites were related to sperm concentration and count, respectively, and they are mainly involved in fatty acid, lipid and amino acid metabolism. Moreover, it was further indicated that eicosatetraenoate, carnitines and DHA may impact the inverse association between DMA and sperm concentration, while eicosatetraenoate, carnitines, DHA, PGB2 and tocotrienol are possible mediators of the positive association between PFHxS and sperm concentration. As these metabolic biomarkers are relevant to antioxidation and fatty acid β-oxidation, we suggest that redox balance and energy generation shifts in seminal plasma are involved in the association of human semen quality with environmental DMA and PFHxS exposure.
环境砷、邻苯二甲酸酯（PAEs）和全氟化合物（PFCs）的暴露与人类精液质量有关。然而，这些关联的流行病学“黑箱”仍然没有得到充分揭示。在这项研究中，基于中国男性人群中砷、PAE 和 PFC 暴露与精液质量参数（即精液量、精子浓度、精子计数、前向运动精子百分率、总运动精子百分率和正常形态精子百分率）之间的关联分析，我们通过 meet-in-metabolite-analysis（MIMA）方法，探索了可能介导暴露-结局关系的精液代谢特征。结果表明，DMA 与精子浓度呈负相关，而 MEHP 和 PFHxS 与精子计数和浓度呈正相关。代谢组学分析表明，有十六种和二十二种精液代谢物分别与精子浓度和计数相关，它们主要涉及脂肪酸、脂质和氨基酸代谢。此外，进一步表明花生四烯酸、肉碱和二十二碳六烯酸可能影响 DMA 与精子浓度之间的负相关，而花生四烯酸、肉碱、二十二碳六烯酸、PGB2 和生育三烯酚可能是 PFHxS 与精子浓度之间正相关的中介物。由于这些代谢生物标志物与抗氧化和脂肪酸β-氧化有关，我们认为精液中氧化还原平衡和能量产生的变化可能参与了人类精液质量与环境 DMA 和 PFHxS 暴露的关联。
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