Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Japanese Red Cross Katsushika Maternity Hospital, Tokyo, Japan.
Int Arch Allergy Immunol. 2019;180(3):202-211. doi: 10.1159/000501636. Epub 2019 Aug 8.
Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of emollients and synbiotics, there is no conclusive evidence on the use of these interventions alone or in combination.
This study is aimed at identifying the efficacy of emollients and synbiotics in preventing AD and FA in children during the first year of life.
The babies of mothers recruited prenatally received either an emollient, synbiotic, both or neither. The intervention was carried out from birth up to 6 months of age. The age of occurrence of AD and FA were reported in multiple questionnaires at 1, 6, and 9 months and at 1 year of age. AD was diagnosed by a pediatrician at 9 months of age.
A -total of 459 babies qualified for the outcome assessment at 1 year of age. Neither the emollient nor the synbiotic showed any effect on reducing the development of AD and FA at 1 year of age.
This study did not provide any evidence to show that emollients and synbiotics, alone or in combination are sufficient to prevent the occurrence of AD or FA in children up to 1 year of age.
特应性皮炎（AD）和食物过敏（FA）是常见的儿童疾病，它们可能相互关联，也可能是皮肤屏障破坏和肠道黏膜失调的结果。虽然有一些证据表明保湿剂和合生剂有效，但单独或联合使用这些干预措施的效果尚无确凿证据。
本研究旨在确定保湿剂和合生剂在预防儿童生命第一年 AD 和 FA 中的作用。
从妊娠期间招募的母亲的婴儿接受保湿剂、合生剂、两者或两者都不接受干预。干预措施从出生持续到 6 个月大。在 1、6 和 9 个月以及 1 岁时，通过多项问卷报告 AD 和 FA 的发病年龄。9 个月时由儿科医生诊断 AD。
共有 459 名婴儿在 1 岁时符合结局评估标准。保湿剂和合生剂均未显示出对降低 1 岁时 AD 和 FA 发展的任何作用。
本研究没有提供任何证据表明保湿剂和合生剂单独或联合使用足以预防儿童在 1 岁前发生 AD 或 FA。
