Laboratory of Ion Channel Research, VIB Center for Brain and Disease Research, Leuven, Belgium; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Laboratory of Endometrium, Endometriosis and Reproductive Medicine, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Trends Pharmacol Sci. 2019 Sep;40(9):669-683. doi: 10.1016/j.tips.2019.07.004. Epub 2019 Aug 5.
Transient receptor potential (TRP) channels are a family of functionally diverse and widely expressed cation channels involved in a variety of cell signaling and sensory pathways. Research in the last two decades has not only shed light on the physiological roles of the 28 mammalian TRP channels, but also revealed the involvement of specific TRP channels in a plethora of inherited and acquired human diseases. Considering the historical successes of other types of ion channels as therapeutic drug targets, small molecules that target specific TRP channels hold promise as treatments for a variety of human conditions. In recent research, important new findings have highlighted the central role of TRP channels in chronic pain, lower urinary tract disorders, and type 2 diabetes, conditions with an unmet medical need. Here, we discuss how these advances support the development of TRP-channel-based pharmacotherapies as valuable alternatives to the current mainstays of treatment.
瞬时受体电位 (TRP) 通道是一类功能多样且广泛表达的阳离子通道，参与多种细胞信号转导和感觉途径。过去二十年的研究不仅阐明了 28 种哺乳动物 TRP 通道的生理作用，还揭示了特定 TRP 通道在多种遗传性和获得性人类疾病中的作用。鉴于其他类型离子通道作为治疗药物靶点的历史成就，靶向特定 TRP 通道的小分子有望成为多种人类疾病的治疗方法。在最近的研究中，重要的新发现强调了 TRP 通道在慢性疼痛、下尿路疾病和 2 型糖尿病中的核心作用，这些疾病存在未满足的医疗需求。在这里，我们讨论这些进展如何支持基于 TRP 通道的药物治疗的发展，作为当前主要治疗方法的有价值的替代方法。
